Director/PDMR Shareholding

Fulcrum Pharma PLC
18 April 2007


                                Fulcrum Pharma plc
                       ('Fulcrum Pharma' or 'the Company')

Directors Shareholding

In accordance with Chapter 5 of the Financial Services Authority's Disclosure
and Transparency Rules, the Company was informed on 18 April 2007, by certain
directors of the Company, of the following interests in the issued voting share
capital of the Company:

Director          Number of Shares     Percentage of issued voting share capital
Dr J P Court       7,634,622                                        4.29
Dr A Devlin        7,093,975                                        3.98

For further information

Seymour Pierce                                                  020 7107 8000

Jonathan Wright
Sarah Wharry




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