Pre Close Statement

Synexus Clinical Research PLC
28 September 2007


Synexus Clinical Research plc ("the Company")

Pre Close Statement

Synexus Clinical Research plc, which provides clinical trials services for the
global pharmaceutical industry, confirms it will release its interim results for
the six months ended 30 September 2007 in the week commencing 3 December 2007.
Prior to entering its close period, the Company today issues a trading update.

As expected, given previously announced delays to major contracts, trading in
the first half has been challenging. However, significant new contract wins
since 31 March 2007 mean that the Company's forward order book is presently at a
record level of £18.5m with a further £19.0m of outstanding bid proposals.

The Directors remain confident about the prospects for the Company for the
remainder of the financial year.

Press enquiries

Synexus Clinical Research plc                   Tel: [phone]

Michael Fort, Chief Executive

Paul McCluskey, Chief Financial Officer

Biddicks - Financial Public Relations           Tel: [phone]

Zoe Biddick


Brewin Dolphin - NOMAD Tel: [phone]

Mark Brady/Alison Barrow




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