Holding(s) in Company

Synexus Clinical Research PLC
22 August 2007


TR-1(i): NOTIFICATION OF MAJOR INTERESTS IN SHARES


1. Identity of the issuer or the underlying issuer of existing shares to which
voting rights are attached (ii):


SYNEXUS CLINICAL RESEARCH PLC


2. Reason for the notification (please state Yes/No): ( )


An acquisition or disposal of voting rights: (YES)


An acquisition or disposal of financial instruments which may result in the
acquisition of shares already issued to which voting rights are attached: ( )


An event changing the breakdown of voting rights: ( )


Other (please specify) : ( )


3. Full name of person(s) subject to the notification obligation (iii):


BREWIN DOLPHIN SECURITIES LIMITED


4. Full name of shareholder(s) (if different from 3.) (iv):


5. Date of the transaction (and date on which the threshold is crossed or
reached if different) (v):


20 AUGUST 2007


6. Date on which issuer notified:


21 AUGUST 2007


7. Threshold(s) that is/are crossed or reached:


5%


8. Notified details:


A: Voting rights attached to shares

Class/type of shares if possible using    Situation previous to the Triggering
the ISIN CODE                                       transaction (vi)
                                        Number of      Number of voting Rights
                                        shares         (viii)

ORDINARY SHARES                         1,203,541                 1,203,541
GB00B0L20P03



Resulting situation after the triggering transaction (vii)

Class/type of shares if         Number of  Number of voting     % of voting
possible using the ISIN CODE    shares     rights (ix)          rights

                                Direct     Direct  Indirect     Direct Indirect
                                           (x)     (xi)

ORDINARY SHARES                 N/A        N/A      1,096,076   N/A     4.7338%
GB00B0L20P03


B: Financial Instruments

Resulting situation after the triggering transaction (xii)

Type of     Expiration Exercise/       Number of voting rights that may  % of
financial   Date       Conversion      be acquired if the instrument is  voting
instrument  (xiii)     Period/ Date    exercised/ converted.             rights
                       (xiv)







Total (A+B)
Number of voting rights                      % of voting rights

      1,096,076                              4.7338%


9. Chain of controlled undertakings through which the voting rights and/or the
financial instruments are effectively held, if applicable (xv):


INDIRECT - BREWIN NOMINEES (CHANNEL ISLANDS) LIMITED - 38,770 - 0.1674%

INDIRECT - BREWIN NOMINEES LIMITED - 50,769 - 0.2193%

INDIRECT - GILTSPUR NOMINEES LIMITED - 929,803 - 4.0157%

INDIRECT - FOUR YARDS NOMINEES LIMITED - 23,000 - 0.0994%

INDIRECT - BREWIN NOMINEES LIMITED A/C CHARITY - 53,734 - 0.232%


Proxy Voting:


10. Name of the proxy holder:

.................


11. Number of voting rights proxy holder will cease to hold:

.................


12. Date on which proxy holder will cease to hold voting rights:

.................


13. Additional information:


FIGURES BASED ON SHARES IN ISSUE OF 23,154,172.


THE INDIRECT VOTING RIGHTS UNDER (9) RELATE TO SHARES HELD IN CLIENT PORTFOLIOS,
MANAGED BY THOSE FIRMS, UNDER DISCRETIONARY INVESTMENT MANAGEMENT AGREEMENTS.


14. Contact name:


KATIE EDWARDS


15. Contact telephone number:

0191 279 7678




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