Holding(s) in Company

Smith & Nephew Plc
21 April 2008




                   NOTIFICATION OF MAJOR INTERESTS IN SHARES


1. Name of company

Smith & Nephew plc


2. Name of shareholder having a major interest

Capital Research and Management Company


3. Please state whether notification indicates that it is in respect of holding
of the shareholder named in 2 above or in respect of a non-beneficial interest
or in the case of an individual holder if it is a holding of that person's
spouse or children under the age of 18

Non-beneficial


4. Name of the registered holder(s) and, if more than one holder, the number of
shares held by each of them

...............................................................

5. Number of shares / amount of stock acquired

...............................................................


6. Percentage of issued class

...............................................................


7. Number of shares / amount of stock disposed

2,043,259


8. Percentage of issued class

Less than 0.3%...............................................................


9. Class of security

Ordinary shares of US 20 cents


10. Date of transaction

17.04.2008


11. Date company informed

18.04.2008


12. Total holding following this notification

43,658,771


13. Total percentage holding of issued class following this notification

4.9048%


14. Any additional information

...............................................................


15. Name of contact and telephone number for queries

Gemma Parsons - Assistant Company Secretary

020 7960 2228


16. Name and signature of authorised company official responsible for making
this notification

Gemma Parsons - Assistant Company Secretary


Date of notification

21.04.08


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