Holding(s) in Company

Smith & Nephew Plc
21 September 2005

                   NOTIFICATION OF MAJOR INTERESTS IN SHARES

1. Name of company

Smith & Nephew plc

2. Name of shareholder having a major interest

The Capital Group Companies, Inc.

3. Please state whether notification indicates that it is in respect of holding
of the shareholder named in 2 above or in respect of a non-beneficial interest
or in the case of an individual holder if it is a holding of that person's
spouse or children under the age of 18

Non-beneficial

4. Name of the registered holder(s) and, if more than one holder, the number of
shares held by each of them

Capital Guardian Trust Company:
State Street Nominees Ltd   50,850
Bank Of New York Nominees Ltd   527,443
Chase Manhattan Bank Australia Ltd   5,200
Chase Nominees Ltd   4,027,313
BT Globenet Nominees Ltd   53,900
Midland Bank plc   24,200
Cede & Co   45,800
Nortrust Nominees 1,091,540
Royal Bank of Scotland   5,500
MSS Nominees Ltd   13,400
State Street Bank & Trust Co   3,000
RBSTB Nominees Ltd    3,100
Deutsche Bank AG 1,800
ROY Nominees Ltd   3,500
Mellon Nominees (UK) Ltd   42,200
JP Morgan Chase Bank   492,500

Capital International Ltd:
State Street Nominees Ltd   14,400
Bank of New York Nominees   547,665
Northern Trust   294,344
Chase Nominees Ltd   355,793
Midland Bank plc   22,900
Bankers Trust   16,400
Morgan Guaranty   57,500
Nortrust Nominees   597,126
State Street Bank & Trust Co   22,500
Deutsche Bank AG   105,941
HSBC Bank plc  156,965
Mellon Bank NA 13,800
Bank One London  24,400

Capital International SA:
Chase Nominees Ltd   85,952

Capital Research and Management Company:
State Street Nominees Ltd   9,384,000
Chase Nominees Ltd   19,650,000

5. Number of shares / amount of stock acquired

Not disclosed

6. Percentage of issued class

Not disclosed

7. Number of shares / amount of stock disposed

...............................................................

8. Percentage of issued class

...............................................................

9. Class of security

Ordinary shares of 12 2/9p

10. Date of transaction

...............................................................


11. Date company informed

20.09.05

12. Total holding following this notification

37,740,932

13. Total percentage holding of issued class following this notification

4.019%

14. Any additional information

...............................................................

15. Name of contact and telephone number for queries

Phil Higgins - Assistant Company Secretary

020 7960 2228

16. Name and signature of authorised company official responsible for making
this notification

Phil Higgins - Assistant Company Secretary

Date of notification

21.09.05

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for loss of business or loss of profits) arising in contract, tort or otherwise
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