Issue of Options

(AIM: SAR)   22 December 2010


                              SAREUM HOLDINGS PLC

                          ("Sareum" or the "Company")


                                Issue of Options

The  Company  announces  that  it  has  granted the following share options (the
"Options")  to Tim  Mitchell (Chief  Executive Officer)  and John  Reader (Chief
Scientific Officer) (together, the "Directors");

                Number of options

 Tim Mitchell           6,153,846

 John Reader            6,153,846


The Options have been granted with an exercise price of 0.26 pence.

Of the Options granted to each Director, 3,076,923 will vest immediately and are
exercisable  until 22 December 2020. The  remaining 3,076,923 options will vest,
subject  to the discretion of the Remuneration  Committee of the Company, on the
date  upon which a significant commercial deal  is signed by the Company and are
thereafter capable of being exercised until 22 December 2020.

In  addition  to  the  options  being  granted the Directors currently each hold
options over 6,400,000 shares, which were granted on 4 December 2009

Enquires:

 Sareum Holdings plc

 Tim Mitchell                       01223 497 700



 Merchant Securities Limited (Nominated Adviser)

 Simon Clements/Bidhi Bhoma         020 7628 2200



 Hybridan LLP (Broker)

 Claire Noyce                       020 7947 4350


Notes for editors:

About Sareum Holdings plc

Sareum  is  a  drug  discovery  company,  headquartered in Cambridge UK, that is
focused  on  producing  targeted  small  molecule  therapeutics to address unmet
medical needs, primarily in cancer.

Sareum   aims   to   successfully  deliver  drug  candidates  for  licensing  to
pharmaceutical and biotechnology companies at the pre-clinical or early clinical
trials stage.

Sareum  Holdings  plc  joined  the  AIM  market  of the London Stock Exchange in
October  2004, trading under  the symbol  SAR.  For  further information, please
visitwww.sareum.co.uk







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Source: SAREUM HOLDINGS PLC via Thomson Reuters ONE

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