Re Agreement

Aortech International PLC 23 May 2001 AORTECH INTERNATIONAL PLC TruCCOMS European Distribution Agreement TruCOMMS adopted by two key European centres AorTech International plc ('AorTech' or the 'Company'), the Scottish-based developer and manufacturer of cardio-vascular devices and biomaterials, today announces the signing of a distribution agreement for its TruCCOMS Continuous Cardiac Output Monitoring System with BD ('Becton, Dickinson and Company') one of the world's leading medical device companies. The distribution agreement is exclusive for the Europe and Middle East markets. The TruCCOMS system, which is unique, provides real time continuous cardiac output monitoring for patients in the critical care environment. Eddie McDaid, Chief Executive AorTech International plc, commented: 'This agreement will enable AorTech to implement and expand the marketing and sales of our TruCCOMS products throughout Europe and the Middle East via the substantial resources of BD sales network. We have already made initial sales in these areas and surgeons and clinicians are already recognising the benefits of our TruCCOMS system in the control of management of patients in the critical care environment.' Bill Marshall, VP, Infusion and Technique Products for BD said: 'Our early assessment of the TruCCOMS system indicates the potential market impact which AorTech's real time continuous cardiac output monitoring system will provide for patients in the critical care environment. TruCCOMS will be added to our own product lines in the critical care environment and will form a key focus of our European sales team efforts.' In addition, two key centres in Europe have adopted AorTech's new pulmonary artery catheter technology (TruCCOMS) within the critical area of coronary artery by-pass graft surgery (CABG). The Badoyenhausen Hertz Centre in Germany has begun the use of TruCCOMS during some routine CABG surgery. Badoyenhausen Hertz Centre performs more than four thousand five hundred open heart procedures per year and currently uses two and a half thousand pulmonary artery catheters per year. It is one of the largest heart centres in the world and also excels in the areas of heart transplantation, paediatric heart surgery and implantation of heart assist devices. Professor Koerfer, the chief cardiac surgeon of the centre said: 'During routine CABG surgery TruCCOMS accurately reflected changes in cardiac output as each new graft was attached. The speed of response was particularly important to us where changes in cardiac output were displayed within seconds.' The Villa Maria Hospital Group in Italy has also adopted the TruCCOMS realtime cardiac output monitoring system for use on patients undergoing off-pump CABG surgery. The Villa Maria Group represents a consortium of 10 hospitals in Italy and is the country's leader in international cardiology and vascular surgery as well as cardio pulmonary surgery. The Group's hospitals together perform more than 10% of the cardiac surgery done in Italy. Dr Bruno Biagi, Vice President of the Groups Scientific department, explained his decision to adopt the new system saying: 'We evaluated TruCCOMS and found that its immediate response to cardiac manipulations was particularly useful in tracking changes inflow during off-pump surgery.... the monitor allowed us to guide surgery and provided confirmation of the patency of the coronary grafts as they were completed. The monitor quickly and accurately detects important changes in cardiac output.' Off-pump CABG surgery is carried out by cardiac surgeons on the patient's beating heart and is a procedure increasingly used by cardiac surgeons throughout the world. AorTech launched the initial sales of the TruCCOMS system in January 2001 and sales have already been made in several countries. 23 May 2001 ENQUIRIES: AorTech International plc Tel: 01698 746699 Eddie McDaid, Chief Executive Officer College Hill Tel: 020 7457 2020 Michael Padley / Nicholas Nelson
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