Holding(s) in Company

Provexis PLC 14 September 2007 TR-1: NOTIFICATION OF MAJOR INTEREST IN SHARES 1. Identity of the issuer or the underlying issuer of existing shares to which voting rights are attached PROVEXIS PLC 2. Reason for the notification (please tick the appropriate box or boxes) An acquisition or disposal of voting rights (X) An acquisition or disposal of financial instruments which may ( ) result in the acquisition of shares already issued to which voting rights are attached An event changing the breakdown of voting rights ( ) Other (specify): ( ) 3. Full name of person(s) subject to the notification obligation: Cantor Fitzgerald Europe 4. Full name of shareholder(s) (if different from 3.) 5. Date of the transaction (and date on which the threshold is crossed or reached if different): 11/09/07 6. Date on which issuer notified: 13/09/07 7. Threshold(s) that is/are crossed or reached: Below 3% 8. Notified details: A. Voting rights attached to shares Class/type of shares (if possible using the Ordinary (GB00B0923P27) ISIN code) Situation previous to Resulting situation after the triggering transaction the triggering transaction Number of Number of Number of Number of voting % of voting rights Shares Voting shares rights Rights Direct Direct Indirect Direct Indirect 26,991,666 26,991,666 11,991,666 11,991,666 2.99 B. Financial Instruments Resulting situation after the triggering transaction Type of Expiration Exercise/ Number of voting % of voting financial date Conversion Period/ rights that may rights instrument Date be acquired if the instrument is exercised/ converted Total (A+B) Number of voting rights % of voting rights 11,991,666 2.99 9. Chain of controlled undertakings through which the voting rights and/ or the financial instruments are effectively held, if applicable: Proxy Voting: 10. Name of the proxy holder: N/A 11. Number of voting rights proxy N/A holder will cease to hold: 12. Date on which proxy holder N/A will cease to hold voting rights: 13. Additional information: 14: Contact name: Ross Tanton 15. Contact telephone number: 020 7894 7214 This information is provided by RNS The company news service from the London Stock Exchange OLSFLFLLSWSESU

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Provexis (PXS)
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