Holding(s) in Company

Provexis PLC
27 March 2008

TR-1: NOTIFICATION OF MAJOR INTEREST IN SHARES

1.  Identity of the issuer or the underlying issuer of existing shares to
    which voting rights are attached

    PROVEXIS PLC

2.  Reason for the notification (please tick the appropriate box or boxes)

    An acquisition or disposal of voting rights                       (X)

    An acquisition or disposal of financial instruments which may     ( )
    result in the acquisition of shares already issued to which
    voting rights are attached

    An event changing the breakdown of voting rights                  ( )

    Other (specify):                                                  ( )

3.  Full name of person(s) subject to the notification obligation:

    Credit Agricole Cheuvreux International Ltd

4.  Full name of shareholder(s) (if different from 3.)

    Credit Agricole Cheuvreux International Ltd

5.  Date of the transaction (and date on which the threshold is crossed
    or reached if different):

    19 Mar 2008

6.  Date on which issuer notified:

    25 Mar 2008 (received by issuer on 26 Mar 2008)

7.  Threshold(s) that is/are crossed or reached:

    5%

8.  Notified details:

A. Voting rights attached to shares

Class/type of shares (if possible using the           Ordinary (GB00B0923P27)
ISIN code)

Situation previous to   Resulting situation after the triggering transaction
the triggering
transaction
Number of   Number of   Number of   Number of voting      % of voting rights
Shares      Voting      shares      rights
            Rights
                        Direct      Direct     Indirect   Direct    Indirect

15,000,000  15,000,000  20,203,500  20,203,500            5.03%


B. Financial Instruments

Resulting situation after the triggering transaction
Type of       Expiration   Exercise/          Number of voting  % of voting
financial     date         Conversion Period/ rights that may   rights
instrument                 Date               be acquired if
                                              the instrument is
                                              exercised/
                                              converted

Total (A+B)
Number of voting rights              % of voting rights

20,203,500                           5.03%

9.  Chain of controlled undertakings through which the voting rights and/
    or the financial instruments are effectively held, if applicable:

    SAS Rue la Boetie
    Credit Agricole SA
    Calyon SA
    Credit Agricole Cheuvreux SA 20,203,500 (5.03%)

Proxy Voting:

10.  Name of the proxy holder:

11.  Number of voting rights proxy
     holder will cease to hold:

12.  Date on which proxy holder
     will cease to hold voting
     rights:


13.  Additional information:

14:  Contact name:                 Gabrielle Burne

15.  Contact telephone number:     020 7214 6037




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