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Proteome Sciences PLC 02 April 2003 PRESS RELEASE Proteome Sciences Announces Licensing Agreement and Collaboration with IDEXX Laboratories on Biomarkers for Diagnosis of Mad Cow Disease 2nd April 2003 Proteome Sciences plc (Proteome Sciences) announced today that it has entered into a licensing and collaboration agreement with IDEXX Laboratories, Inc. (Nasdaq:IDXX), for its Bovine Spongiform Encephalopathy (BSE) biomarkers. This contract follows the licensing agreement announced last December with Biosite for Proteome Sciences biomarkers in blood for stroke and provides strong endorsement of the value and the utility of Proteome Sciences technology. The licensing agreement grants IDEXX Laboratories, a world leader in veterinary diagnostics, exclusive global rights to develop and commercialise diagnostic assays for the detection of BSE in cattle and Transmissible Spongiform Encephalopathies (TSEs) in other animals. The EU cattle population totaled 80 million in 2001. The BSE market for post mortem testing of cattle was €105m, with the EU paying €15 for each test kit. Experts estimate that the demand could grow to 30 million tests in the EU, projecting a future market size of €450m. These figures exclude any demand from the USA, which has an estimated 100 million cattle population. The global market for live animal testing for BSE using a simple blood test is expected to be much larger and IDEXX will use Proteome Sciences proprietary biomarkers to seek to develop highly sensitive blood assays for the testing of live animals. Current detection methods require brain tissue or spinal cord samples from slaughtered animals. Under the terms of the agreement, Proteome Sciences will receive upfront and milestone payments and royalties on sales of products incorporating Proteome Sciences biomarkers. Commenting, Christopher Pearce, Chief Executive Officer of Proteome Sciences said: 'This deal endorses our research strategy to address protein changes and to concentrate on high sensitivity differential expression of disease markers. The results provided to IDEXX in a pilot study clearly demonstrated the power of our technology and we are delighted to conclude an agreement with them to develop a blood test for BSE in live cattle. In addition to BSE and stroke, we have a range of other biomarker research programmes that are coming through to commercialisation. These, coupled with our high throughput state-of-the-art proteomics facilities in Frankfurt and London, leave us strongly positioned to capitalize on the rapid growth in proteomics which is forecast to reach $5.6 billion in 2005.' Commenting, Dr. Quentin Tonelli, Vice President of IDEXX said: 'BSE and other TSEs are important health concerns. The veterinary market currently has no proven diagnostics for BSE in live cattle. Proteome Sciences proprietary proteomic technologies and identification of novel protein markers in blood will enhance our efforts to develop products to serve this major unmet need in veterinary diagnostics.' ENDS For further information please contact: Proteome Sciences plc Tel: +44 (0) 1932 865065 Christopher Pearce, Chief Executive e-mail: christopher.pearce@proteome.co.uk www.proteome.co.uk James Green, Commercial Director Tel: +44 (0) 7768 026962 e-mail: james.green@proteome.co.uk Ian Pike, Business Development Manager Tel: +44 (0) 1932 865065 e-mail: ian.pike@proteome.co.uk Public Relations for Proteome Sciences Ikon Associates Adrian Shaw Tel: +44 (0) 1483 271291 Mobile: + 44(0) 797 9900733 e-mail: adrian@ikon-associates.com IDEXX Incorporated Tel: +1 207 856 0300 Elizabeth Perry, Investor Relations betsy-perry: @idexx.com www.idexx.com Note to Editors Proteome Sciences plc applies high sensitivity proteomics to identify and characterise differential protein expression in diseases for diagnostic, prognostic and therapeutic applications. It has to date developed sensitive blood assays for stroke, nvCJD, BSE and solid organ transplant rejection. The main focus of its research currently addresses neurological, neurodegenerative, diabetes/obesity, oncology and cardiovascular conditions. Commercialisation of these programmes will be effected through strategic alliances and licensing agreements. Proteome Sciences is headquartered in Cobham, Surrey in the UK and has laboratories at Kings College Hospital, London and in Frankfurt. It employs 40 full time scientists in addition to its corporate and business development staff. The Company has been listed on the Alternative Investment Market since 1994. IDEXX Laboratories, Inc. is a worldwide leader in the development and commercialization of innovative, technology-based products and services for animal health. The Company's largest business is focused on companion animal health, combining biotechnology, medical device technology and information technology to aid veterinarians in providing better medicine while building successful practices. IDEXX Laboratories is also focused on employing innovative technologies to monitor production animal health and the safety and quality of drinking water and milk. Headquartered in Westbrook, Maine, IDEXX Laboratories employs more than 2,100 people and offers products to customers in more than 50 countries. This information is provided by RNS The company news service from the London Stock Exchange
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