Holding(s) in Company

Proteome Sciences PLC
28 April 2004


                     Proteome Sciences PLC ('the Company')

                               Holding in Company

The Company was today notified by Credit Lyonnais Securities that it has an
interest in 6,996,000 ordinary shares of 1p each ('Ordinary Shares'),
representing approximately 5.8 per cent. of the Company's issued Ordinary Share
capital.

28 April 2004

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