Holding(s) in Company

Proteome Sciences PLC
04 August 2004

                     Proteome Sciences plc ('the Company')

Proteome Sciences plc was today advised that FMR Corp. and its direct & indirect
subsidiaries and Fidelity International Limited and its direct and indirect
subsidiaries and Mr Edward C. Johnson 3rd (A principal shareholder of FMR Corp /
Fidelity International Limited) have a notifiable interest in 9,542,141 ordinary
shares, representing 7.796% of the companies issued ordinary share capital.


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