Holding(s) in Company

Proteome Sciences PLC
23 April 2004


                     Proteome Sciences PLC ('the Company')

                               Holding in Company

The Company was notified on 23 April 2004 by Lansdowne Partners Limited
Partnership that, as a result of a purchase of shares, it has an interest in a
total of 3,686,206 ordinary shares of 1p each ('Ordinary Shares'), representing
approximately 3.06 per cent. of the Company's issued Ordinary Share capital.

23 April 2004




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