Holding(s) in Company

Proteome Sciences PLC
03 February 2004


                     Proteome Sciences PLC ('the Company')

                               Holding in Company

The Company was notified on 3 February 2004 by Fidelity Investments that FMR
Corp. as the parent and holding company of Fidelity Management & Research
Company ('FMRCO'), Fidelity Management Trust Company ('FMTC'), Fidelity
International Limited ('FIL') and Fidelity Investment Services Ltd. ('FISL') has
a non-beneficial interest in a total of 7,232,221 ordinary shares of 1p each
('Ordinary Shares'), representing approximately 6.00 per cent. of the Company's
issued Ordinary Share capital.

Edward C. Johnson III also has a notifiable interest by virtue of his
shareholding in FMR Corp. and FIL.

The above shares are held as follows:

Shares Held     Management Company             Nominee/Registered Name

    348,907           FMRCO                          Mellon Bank
  4,891,300            FISL                  Chase Manhattan Bank London
     72,000            FIL                Brown Brothers Harriman Ltd. LUX
    502,300            FIL                   Chase Manhattan Bank London
  1,021,714            FIL                              HSBC
     37,100            FIL                    State Street Bank & Trust
     34,600            FIL                     Bank of New York London
    118,600            FIL                       Chase Nominees Ltd
     70,600            FIL                          Bankers Trust
    135,100            FIL                            Citibank

3 February 2004




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