Holding(s) in Company

Proteome Sciences PLC
22 September 2003



Proteome Sciences Plc ('the Company')

NOTIFICATION OF MAJOR INTERESTS IN SHARES

Disclosure Under Section 198 of the Companies Act

The Company received a notification today from Credit Lyonnais Securities
informing it that they have an interest in 4,053,500 ordinary shares
representing 3.4% of the ordinary issued share capital of the Company.



22 September, 2003




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