Grant of Options

Proteome Sciences PLC
12 January 2001

                                 SCHEDULE 11

         NOTIFICATION OF INTERESTS OF DIRECTORS AND CONNECTED PERSONS

1) Name of company

Proteome Sciences plc

2) Name of directors

C.D.J. Pearce

J.L. Malthouse

3) Please state whether notification indicates that it is in respect of
holding of the shareholder named in 2 above or in respect of a non-beneficial
interest or in the case of an individual holder if it is a holding of that
person's spouse or children under the age of 18 or in respect of a
non-beneficial interest

As in 2 above

4) Name of the registered holder(s) and, if more than one holder, the
number of shares held by each of them (if notified)

As in 2 above

5) Please state whether notification relates to a person(s) connected
with the Director named in 2 above and identify the connected person(s)

N/A

6) Please state the nature of the transaction. For PEP transactions
please indicate whether general/single co PEP and if discretionary/non
discretionary


7) Number of shares/amount of
stock acquired

8) Percentage of issued class

9) Number of shares/amount
of stock disposed

10) Percentage of issued class

11) Class of security

12) Price per share

13) Date of transaction


14) Date company informed


15) Total holding following this notification


16) Total percentage holding of issued class following this notification


If a director has been granted options by the company please complete the
following boxes

17) Date of grant

12th January 2001

18) Period during which or date on which exercisable

12th January 2004 to 11th January 2008

19) Total amount paid (if any) for grant of the option

N/A

20) Description of shares or debentures involved: class, number

Ordinary shares of 1p

C.D.J. Pearce - 126,190


J.L. Malthouse - 51,671

21) Exercise price (if fixed at time of grant) or indication that price
is to be fixed at time of exercise

89p

22) Total number of shares or debentures over which options held
following this notification

C.D.J. Pearce - Options - 1,879,774

Warrants - 642,840

J.L. Malthouse - Options - 1,473,375

23) Any additional information



24) Name of contact and telephone number for queries

Jim Carroll [phone]

25) Name and signature of authorised company official responsible for
making this notification

Date of Notification.........12th January, 2001......................