Directors' Notification of Dealing in Shares

Proteome Sciences PLC
31 March 2000

Schedule 11 - Notification of interests of Directors and Connected Persons

1   Name of company:
PROTEOME SCIENCES PLC

2   Name of director:
J L MALTHOUSE-

3   Please state whether notification indicates that it is in respect of     
holding of the director named in 2 above or holding of that person's spouse or
children under the age of 18 or in respect of a non- beneficial interest:
THE DIRECTOR IN 2 ABOVE

4   Name of registered holder(s) and, if more than one holder, the number of 
shares held by each of them (if notified):
-

5   Please state whether notification relates to a person(s) connected with  
the director named in 2 above and identify the connected person(s):
-

6   Please state the nature of the transaction. For PEP transactions please  
indicate whether general/single co PEP and if discretionary/non discretionary:
-

7   Number of shares/amount of stock acquired:
-

8   Percentage of issued class:
-

9   Number of shares/amount of stock disposed:
-

10  Percentage of issued class:
-

11  Class of security:
-

12  Price per share:
-

13  Date of transaction:
-

14  Date company informed:
-

15  Total holding following this notification:
-

16  Total percentage holding of issued class following this notification:
-

If a director has been granted options by the company, please complete the
following fields:

17  Date of grant:
30 MARCH 2000

18  Period during which or date on which exercisable:
31.3.03 TO 31.03.07

19  Total amount paid (if any) for grant of the option:
-

20  Description of shares or debentures involved: class, number:
200,000 ORDINARY SHARES OF 1p

21  Exercise price (if fixed at time of grant) or indication that price is to
be fixed at time of exercise:
61p

22  Total number of shares or debentures over which options held following
this notification:
1,421,804

23  Contact name for queries:
WAYNE SLYFIELD

24  Contact telephone number:
020 7638 4010

25  Name of company official responsible for making notification:
J L MALTHOUSE


Additional Information: