Directors' Notification of Dealing in Shares

Proteome Sciences PLC
25 April 2000




Schedule 11 - Notification of interests of Directors and Connected Persons

1   Name of company:
PROTEOME SCIENCES plc

2   Name of director:
CHRISTOPHER DONOVAN JAMES PEARCE

3   Please state whether notification indicates that it is in respect of     
holding of the director named in 2 above or holding of that person's spouse or
children under the age of 18 or in respect of a non- beneficial interest:
THE DIRECTOR NAMED IN 2 ABOVE

4   Name of registered holder(s) and, if more than one holder, the number of 
shares held by each of them (if notified):
C D J PEARCE

5   Please state whether notification relates to a person(s) connected with  
the director named in 2 above and identify the connected person(s):
-

6   Please state the nature of the transaction. For PEP transactions please  
indicate whether general/single co PEP and if discretionary/non discretionary:
SHARES TAKEN UP UNDER THE OPEN OFFER/PLACING

7   Number of shares/amount of stock acquired:
222,222

8   Percentage of issued class:
0.24%

9   Number of shares/amount of stock disposed:
-

10  Percentage of issued class:
-

11  Class of security:
ORDINARY SHARES OF 1p EACH

12  Price per share:
45p

13  Date of transaction:
20 APRIL 2000

14  Date company informed:
20 APRIL 2000

15  Total holding following this notification:
4,323,222

16  Total percentage holding of issued class following this notification:
4.72%

If a director has been granted options by the company, please complete the
following fields:

17  Date of grant:
20 APRIL 2000

18  Period during which or date on which exercisable:
21.4.2003 - 21.4.2007

19  Total amount paid (if any) for grant of the option:
-

20  Description of shares or debentures involved: class, number:
ORDINARY SHARES OF 1p EACH - 433,124

21  Exercise price (if fixed at time of grant) or indication that price is to
be fixed at time of exercise:
45p

22  Total number of shares or debentures over which options held following
this notification:
OPTIONS: 2,186,708; WARRANTS: 642,840

23  Contact name for queries:
JAMES MALTHOUSE

24  Contact telephone number:
0192 865065

25  Name of company official responsible for making notification:
JIM CARROLL




Schedule 11 - Notification of interests of Directors and Connected Persons

1   Name of company:
PROTEOME SCIENCES plc

2   Name of director:
PROFESSOR KEITH ROBERT LEONARD MANSFORD

3   Please state whether notification indicates that it is in respect of     
holding of the director named in 2 above or holding of that person's spouse or
children under the age of 18 or in respect of a non- beneficial interest:
THE DIRECTOR NAMED IN 2 ABOVE

4   Name of registered holder(s) and, if more than one holder, the number of 
shares held by each of them (if notified):
-

5   Please state whether notification relates to a person(s) connected with  
the director named in 2 above and identify the connected person(s):
-

6   Please state the nature of the transaction. For PEP transactions please  
indicate whether general/single co PEP and if discretionary/non discretionary:
-

7   Number of shares/amount of stock acquired:
-

8   Percentage of issued class:
-

9   Number of shares/amount of stock disposed:
-

10  Percentage of issued class:
-

11  Class of security:
-

12  Price per share:
-

13  Date of transaction:
-

14  Date company informed:
-

15  Total holding following this notification:
-

16  Total percentage holding of issued class following this notification:
-

If a director has been granted options by the company, please complete the
following fields:

17  Date of grant:
20 APRIL 2000

18  Period during which or date on which exercisable:
21.4.2003 - 21.4.2007

19  Total amount paid (if any) for grant of the option:
-

20  Description of shares or debentures involved: class, number:
ORDINARY SHARES OF 1p EACH - 69,444

21  Exercise price (if fixed at time of grant) or indication that price is to
be fixed at time of exercise:
45p

22  Total number of shares or debentures over which options held following
this notification:
69,444

23  Contact name for queries:
JAMES MALTHOUSE

24  Contact telephone number:
01932 865065

25  Name of company official responsible for making notification:
JIM CARROLL




Schedule 11 - Notification of interests of Directors and Connected Persons

1   Name of company:
PROTEOME SCIENCES plc

2   Name of director:
RALPH STEPHEN HARRIS

3   Please state whether notification indicates that it is in respect of     
holding of the director named in 2 above or holding of that person's spouse or
children under the age of 18 or in respect of a non- beneficial interest:
THE DIRECTOR NAMED IN 2 ABOVE

4   Name of registered holder(s) and, if more than one holder, the number of 
shares held by each of them (if notified):
RALPH STEPHEN HARRIS

5   Please state whether notification relates to a person(s) connected with  
the director named in 2 above and identify the connected person(s):
THE DIRECTOR NAMED IN 2 ABOVE

6   Please state the nature of the transaction. For PEP transactions please  
indicate whether general/single co PEP and if discretionary/non discretionary:
SHARES TAKEN UP UNDER THE OPEN OFFER

7   Number of shares/amount of stock acquired:
22,800

8   Percentage of issued class:
0.02%

9   Number of shares/amount of stock disposed:
-

10  Percentage of issued class:
-

11  Class of security:
ORDINARY SHARES OF 1p EACH

12  Price per share:
45p

13  Date of transaction:
20 APRIL 2000

14  Date company informed:
20 APRIL 2000

15  Total holding following this notification:
153,000

16  Total percentage holding of issued class following this notification:
0.17%

If a director has been granted options by the company, please complete the
following fields:

17  Date of grant:
20 APRIL 2000

18  Period during which or date on which exercisable:
21.4.2003 - 21.4.2007

19  Total amount paid (if any) for grant of the option:
-

20  Description of shares or debentures involved: class, number:
ORDINARY SHARES OF 1p EACH - 95,000

21  Exercise price (if fixed at time of grant) or indication that price is to
be fixed at time of exercise:
45p

22  Total number of shares or debentures over which options held following
this notification:
178,300

23  Contact name for queries:
JAMES MALTHOUSE

24  Contact telephone number:
01932 865065

25  Name of company official responsible for making notification:
JIM CARROLL




Schedule 11 - Notification of interests of Directors and Connected Persons

1   Name of company:
PROTEOME SCIENCES plc

2   Name of director:
PROFESSOR WILLIAM DAWSON

3   Please state whether notification indicates that it is in respect of     
holding of the director named in 2 above or holding of that person's spouse or
children under the age of 18 or in respect of a non- beneficial interest:
THE DIRECTOR NAMED IN 2 ABOVE

4   Name of registered holder(s) and, if more than one holder, the number of 
shares held by each of them (if notified):
-

5   Please state whether notification relates to a person(s) connected with  
the director named in 2 above and identify the connected person(s):
-

6   Please state the nature of the transaction. For PEP transactions please  
indicate whether general/single co PEP and if discretionary/non discretionary:
-

7   Number of shares/amount of stock acquired:
-

8   Percentage of issued class:
-

9   Number of shares/amount of stock disposed:
-

10  Percentage of issued class:
-

11  Class of security:
-

12  Price per share:
-

13  Date of transaction:
-

14  Date company informed:
-

15  Total holding following this notification:
-

16  Total percentage holding of issued class following this notification:
-

If a director has been granted options by the company, please complete the
following fields:

17  Date of grant:
20 APRIL 2000

18  Period during which or date on which exercisable:
21.4.2003 - 21.4.2007

19  Total amount paid (if any) for grant of the option:
-

20  Description of shares or debentures involved: class, number:
ORDINARY SHARES OF 1p EACH - 69,444

21  Exercise price (if fixed at time of grant) or indication that price is to
be fixed at time of exercise:
45p

22  Total number of shares or debentures over which options held following
this notification:
69,444

23  Contact name for queries:
JAMES MALTHOUSE

24  Contact telephone number:
01932 865065

25  Name of company official responsible for making notification:
JIM CARROLL




Schedule 11 - Notification of interests of Directors and Connected Persons

1   Name of company:
PROTEOME SCIENCES plc

2   Name of director:
JAMES MALTHOUSE

3   Please state whether notification indicates that it is in respect of     
holding of the director named in 2 above or holding of that person's spouse or
children under the age of 18 or in respect of a non- beneficial interest:
THE DIRECTOR IN 2 -         18,229 SHARES (A)
THE DIRECTOR IN 2 - SPOUSE - 1,875 SHARES (B)

4   Name of registered holder(s) and, if more than one holder, the number of 
shares held by each of them (if notified):
JAMES MALTHOUSE -     18,229 (A)
Mrs HILARY MALTHOUSE - 1,875 (B)

5   Please state whether notification relates to a person(s) connected with  
the director named in 2 above and identify the connected person(s):
-

6   Please state the nature of the transaction. For PEP transactions please  
indicate whether general/single co PEP and if discretionary/non discretionary:
SHARES TAKEN UP UNDER THE OPEN OFFER

7   Number of shares/amount of stock acquired:
(A) 18,229(B) 1,875

8   Percentage of issued class:
(A) 0.02  (B) 0.02

9   Number of shares/amount of stock disposed:
-

10  Percentage of issued class:
-

11  Class of security:
ORDINARY SHARES OF 1p EACH

12  Price per share:
45p

13  Date of transaction:
20 APRIL 2000

14  Date company informed:
20 APRIL 2000

15  Total holding following this notification:
180,937

16  Total percentage holding of issued class following this notification:
0.20%

If a director has been granted options by the company, please complete the
following fields:

17  Date of grant:
-

18  Period during which or date on which exercisable:
-

19  Total amount paid (if any) for grant of the option:
-

20  Description of shares or debentures involved: class, number:
-

21  Exercise price (if fixed at time of grant) or indication that price is to
be fixed at time of exercise:
-

22  Total number of shares or debentures over which options held following
this notification:
-

23  Contact name for queries:
JAMES MALTHOUSE

24  Contact telephone number:
01932 865065

25  Name of company official responsible for making notification:
JIM CARROLL





Additional Information: