Director Shareholding

Proteome Sciences PLC
01 October 2004




                     Proteome Sciences plc ('the Company')


Proteome Sciences plc has been advised on 30 September 2004 that the
undermentioned directors have purchased ordinary shares in the Company on 30
September 2004, as follows:

Name of Director           Shares Purchased              Share Price
------------------         ------------------            --------------
Mr C D J Pearce            50,000                        75p
Mr J L Malthouse           50,000                        75p
  






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