Director Shareholding

Proteome Sciences PLC
09 July 2004



                     Proteome Sciences plc ('the Company')



Proteome Sciences plc announces that the following directors have today been
granted options to subscribe for ordinary shares in the Company at 117.5p per
share under the Unapproved Share Option Scheme:

C D J Pearce                              264,255 shares
J L Malthouse                             159,574 shares
A J Green                                 157,021 shares
Dr. S C Steiner                           153,191 shares




                      This information is provided by RNS
            The company news service from the London Stock Exchange