Director Shareholding

Proteome Sciences PLC
01 August 2003

                                  SCHEDULE 11

          NOTIFICATION OF INTERESTS OF DIRECTORS AND CONNECTED PERSONS

1) Name of company

Proteome Sciences plc

2) Name of director

Professor W. Dawson

3) Please state whether notification indicates that it is in respect of
holding of the shareholder named in 2 above or in respect of a non-beneficial
interest or in the case of an individual holder if it is a holding of that
person's spouse or children under the age of 18 or in respect of a
non-beneficial interest

As in 2 above

4) Name of the registered holder(s) and, if more than one holder, the
number of shares held by each of them (if notified)

N/A

5) Please state whether notification relates to a person(s) connected
with the Director named in 2 above and identify the connected person(s)

As in 2 above

6) Please state the nature of the transaction. For PEP transactions
please indicate whether general/single co PEP and if discretionary/non
discretionary

Exercise of Options, followed by Disposal

7) Number of shares/amount of
stock acquired

69,444 Shares

8) Percentage of issued class

0.06 %

9) Number of shares/amount
of stock disposed

60,000 Shares

10) Percentage of issued class

0.05%

11) Class of security

Ordinary 1p Shares

12) Price per share

Exercised at 45p, sold at 144p

13) Date of transaction

31 July 2003

14) Date company informed

31 July 2003

15) Total holding following this notification

15,124 shares

16) Total percentage holding of issued class following this notification

0.01%

If a director has been granted options by the company please complete the
following boxes

17) Date of grant



18) Period during which or date on which exercisable



19) Total amount paid (if any) for grant of the option



20) Description of shares or debentures involved: class, number



21) Exercise price (if fixed at time of grant) or indication that price
is to be fixed at time of exercise



22) Total number of shares or debentures over which options held
following this notification



23) Any additional information



24) Name of contact and telephone number for queries

James Malthouse 01932 865065

25) Name and signature of authorised company official responsible for
making this notification

Date of Notification...........1 August 2003............



                      This information is provided by RNS
            The company news service from the London Stock Exchange