Director Shareholding

Proteome Sciences PLC
5 June 2002

                                  SCHEDULE 11

          NOTIFICATION OF INTERESTS OF DIRECTORS AND CONNECTED PERSONS

1      Name of Company
       Proteome Sciences plc

2      Name of Director
       J. L. Malthouse

3      Please state whether notification indicates that it is in respect of holding of the shareholder named
       in 2 above or in respect of a non beneficial interest or in the case of an individual holder if it is
       a holding of that person's spouse or children under the age of 18 or in respect of a non-beneficial
       interest
       As 2 Above

4      Name of the registered holder(s) and, if more than one holder, the number of shares held by each of
       them (if notified)
       N/A

5      Please state whether notification relates to a person(s) connected with the Director named in 2 above
       and identify the connected person(s)
       As 2 Above

6      Please state the nature of the transaction. For PEP transactions please indicate whether general/
       single co PEP and if discretionary/non discretionary
       Grant of Options under the Unapproved Scheme
       If a director has been granted options by the company please complete the following boxes

17     Date of grant
       5 June 2002

18     Period during which or date on which exercisable
       5 June 2005 - 5 June 2009

19     Total amount paid (if any) for grant of the option
       Nil

20     Description of shares or debentures involved: class, number
       325,000 Ordinary Shares

21     Exercise price (if fixed at time of grant) or indication that price is to be fixed at time of exercise
       69.25p

22     Total number of shares or debentures over which options held following this notification
       1,581,775

23     Any additional information


24     Name of contact and telephone number for queries
       James Malthouse 01932 865065

25     Name and signature of authorised company official responsible for making this notification
       James Malthouse 01932 865065

26     Date of Notification
       5 June 2002


                      This information is provided by RNS
            The company news service from the London Stock Exchange