Major Interest in Shares

Oxford Biomedica PLC
01 April 2008


For Immediate Release                                            1 April 2008


                              Oxford Biomedica Plc

                  Notifications of Major Interests in Shares
                              Oxford Biomedica Plc

1. Identity of the issuer or the underlying issuer
of existing shares to which voting rights are
attached:

2. Reason for notification (yes/no)
                                                                           Yes

An acquisition or disposal of voting rights

3. Full name of person(s) subject to       Cubana Investments Limited
notification obligation:


4. Full name of shareholder(s) (if
different from 3):

5. Date of transaction (and date on which  1 April 2008
the threshold is crossed or reached if
different):

6. Date on which issuer notified:          1 April 2008

7. Threshold(s) that is/are crossed or     6%
reached:
8: Notified Details
A: Voting rights attached to shares

Class/type   Situation previous to  Resulting situation after the triggering
of shares    the triggering         transaction
             transaction
If possible
use ISIN
code
             Number of   Number of  Number of   Number of voting      Percentage of
             shares      voting     shares      rights                voting rights
                         rights





                         30,597,220
GB0006648157 30,597,220             32,250,791

                                                Direct       Indirect Direct  Indirect



                                                32,250,791            6.00%

B: Financial Instruments

Resulting situation after the triggering transaction

Type of        Expiration date   Exercise/         No. of voting rights Percentage of
financial                        conversion period that may be acquired voting rights
instrument                       /date             (if the instrument
                                                   exercised/converted)


Total (A+B)

Number of voting rights                     Percentage of voting rights
32,250,791                                  6.00%

9. Chain of controlled undertakings through which the voting rights and /or
the financial instruments are effectively held, if applicable:

Proxy Voting:

10. Name of proxy holder:

11. Number of voting rights proxy
holder will cease to hold:

12. Date on which proxy holder will
cease to hold voting rights:

13. Additional information:

14 Contact name:                       Andrew Wood

15. Contact telephone number:          01865 783000







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