Major Interest in Shares

Oxford Biomedica PLC
18 March 2008


For immediate release                                           18 March 2008


                              Oxford BioMedica Plc

               TR-1(i): notification of major interests in shares 



1. Identity of the issuer or the underlying       Oxford BioMedica plc      
issuer of existing shares to which voting                                   
rights are attached(ii):                                                    

2. Reason for the notification (please tick the appropriate box or boxes)    

An acquisition or disposal of voting rights                            YES  

An acquisition or disposal of financial instruments which may result        
in the acquisition of shares already issued to which voting rights          
are attached                                                                

An event changing the breakdown of voting rights                            

Other (please specify):                                                     

3. Full name of person(s) subject to the         Prudential plc group of    
notification obligation(iii):                
4. Full name of shareholder(s) (if different      See attached schedule     
from 3.)(iv):                                                               
the threshold is crossed or reached if                                      
different)(v):                               
6. Date on which issuer notified:                     17 March 2008         

7. Threshold(s) that is/are crossed or                     12%              
reached:                                                                    
8. Notified details:                                                         


A: Voting rights attached to shares                                              

Class/type  Situation previous toResulting situation after the triggering      
of shares   the Triggering       transaction(vii)                              
            transaction (vi)                                                   
(if possible
using the   Number of Number of Number of  Number of voting    % of voting  
ISIN CODE)    Shares    Voting    shares       rights ix         rights     
                        Rights  
                         viii     Direct   Direct x IndirectDirectIndirect
                                                       xi                 

GB000664815763,607,34263,607,34264,607,34264,607,342        12.03%        



B: Financial Instruments                                                      

Resulting situation after the triggering transaction xii                      

    Type of    Expiration     Exercise/      Number of voting  % of voting
   financial    date xiii Conversion Period/rights that may be   rights   
  instrument                   Date xiv       acquired if the             
                                               instrument is              
                                                exercised/                
                                                converted.   
             
      N/A      N/A               N/A        N/A                N/A        



Total (A+B)                                                                  

Number of voting rights              |% of voting rights                     

64,607,342                           |12.03%                                 


                                                                             
                                                                             
                                                                             
9. Chain of controlled undertakings through which the voting rights and/or   
the financial instruments are effectively held, if applicable xv:            

Prudential plc (parent Company)                                              
                                                                             
M&G Group Limited (wholly owned subsidiary of Prudential plc)                
                                                                             
M&G Limited (wholly owned subsidiary of M&G Group Limited)                   
                                                                             
M&G Investment Management Limited (wholly owned subsidiary of M&G Limited)   
                                                                             
M&G Securities Limited (wholly owned subsidiary of M&G Limited)              
                                                                             
The Prudential Assurance Company Limited (wholly owned subsidiary of         
Prudential plc)                                                              



Proxy Voting:                                                                 

10. Name of the proxy holder:                    N/A                         

11. Number of voting rights proxy holder will    N/A                         
cease to hold:                                                               
                                                                         
12. Date on which proxy holder will cease to hold|N/A                         
voting rights:                                                               

13. Additional information:                                                  

14. Contact name:                Andrew Wood                                 
                                                                             
                                 Oxford BioMedica plc                       

15. Contact telephone number:    01865 783000                                


               Registered Holder                            Holding        %

Prudential plc Total Notifiable Interest                 64,607,342   12.03%
               Norturst Nominee Ltd A/C MHF01               134,616
               Nortrust Nominee Ltd A/C MKK01            36,903,494
               Nortrust Noms Ltd                            657,457
               PRUCLT HSBC GIS NOM (UK) PAC AC           18,750,368
               PRUCLT HSBC GIS NOM (UK) PPL AC            8,161,407

M&G Group Limited                                        64,607,342   12.03%
               Norturst Nominee Ltd A/C MHF01               134,616
               Nortrust Nominee Ltd A/C MKK01            36,903,494
               Nortrust Noms Ltd                            657,457
               PRUCLT HSBC GIS NOM (UK) PAC AC           18,750,368
               PRUCLT HSBC GIS NOM (UK) PPL AC            8,161,407

M&G Investment Management Limited                        64,472,726   12.00%
               Nortrust Nominee Ltd A/C MKK01            36,903,494
               Nortrust Noms Ltd                            657,457
               PRUCLT HSBC GIS NOM (UK) PAC AC           18,750,368
               PRUCLT HSBC GIS NOM (UK) PPL AC            8,161,407

M&G Limited                                              64,607,342   12.03%
               Norturst Nominee Ltd A/C MHF01               134,616

               Nortrust Nominee Ltd A/C MKK01            36,903,494

               Nortrust Noms Ltd                            657,457
               PRUCLT HSBC GIS NOM (UK) PAC AC           18,750,368
               PRUCLT HSBC GIS NOM (UK) PPL AC            8,161,407

M&G Securities Limited                                   37,038,110    6.90%
               Norturst Nominee Ltd A/C MHF01               134,616
               Nortrust Nominee Ltd A/C MKK01            36,903,494

The Prudential Assurance Company Limited                 26,911,775    5.01%
               PRUCLT HSBC GIS NOM (UK) PAC AC           18,750,368
               PRUCLT HSBC GIS NOM (UK) PPL AC            8,161,407




















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