Holding(s) in Company

Oxford Biomedica PLC
21 January 2005


Oxford BioMedica plc (the 'Company')

Notification of Major Interests in Shares

The Company has received notification from Prelude Trust plc that on 19 January
2005, Prelude Trust plc sold 1,500,000 ordinary shares of 1p each in Oxford
BioMedica plc. Prelude Trust plc previously held 19,187,346 shares, and
following this sale, the holding of Prelude Trust plc is 17,687,346 1p ordinary
shares. This represents 4.75% of the presently issued share capital of the
Company, which stands at 372,503,634 shares.

Andrew Wood
Chief Financial Officer
Tel [phone]


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