Holding(s) in Company

Oxford Biomedica PLC
05 November 2003

                                  SCHEDULE 10

                   NOTIFICATION OF MAJOR INTERESTS IN SHARES


1.      Name of company

           Oxford BioMedica Plc

2.        Name of shareholder having a major interest

          Prudential plc and certain of its subsidiaries

3.        Please state whether notification indicates that it is in respect of holding of the shareholder
          named in 2 above or in respect of a non-beneficial interest or in the case of an individual
          holder if it is a holding of that person's spouse or children under the age of 18.

          As above

4.        Name of the registered holder(s) and, if more than one holder, the number of shares held by each
          of them
          PRUCLT HSBC GIS NOM (UK) a/c PAC              18,480,000






5.        Number of shares/amount of stock acquired

          Not disclosed

6.        Percentage of issued class

          N/A

7.        Number of shares/amount of stock disposed

          Not disclosed

8.        Percentage of issued class

          N/A

9.        Class of security

          Ordinary shares

10.       Date of transaction

          NOT DISCLOSED

11.       Date company informed

          4th November 2003

12.       Total holding following this notification

          18,480,000 shares

13.       Total percentage holding of issued class following this notification

          4.99%

14.       Any additional information



15.       Name of contact and telephone number for queries

          Andrew Wood 01865 783000

16.       Name and signature of authorised company official responsible for making this notification.

          Andrew Wood CFO Oxford BioMedica

Date of notification: 5 November 2003





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