Grant Awarded

Oxford Biomedica PLC 11 February 2003 11 February 2003 2003/OB/03 OXFORD BIOMEDICA AWARDED €900,000 GRANT Government support for cancer immunotherapy programmes Oxford, United Kingdom 11 February 2003 - Oxford BioMedica announced today that it had been awarded a grant of more than €900,000 to support its immunotherapy programme. The award was made by the UK Department of Trade & Industry under the pan-European Eureka initiative. Oxford BioMedica received the award following its recently announced collaboration with Intervet S.A. to develop TroVax-VET(R) for the treatment of cancer in companion animals. The grant is to support Oxford BioMedica's development of a broad range of applications for 5T4, its proprietary tumour-associated antigen. 5T4 is the active immunogenic component of the Company's lead cancer product TroVax(R), which is entering a number of Phase II clinical trials this year. In addition, an antibody against 5T4 is the subject of Oxford BioMedica's immunotoxin collaboration with Wyeth, a deal worth $24 million in upfront and milestone payments. EUREKA is a pan-European network for market-oriented, industrial R&D. EUREKA supports the competitiveness of European companies through international collaboration, in creating links and networks of innovation. The objective is to bring high quality research and development efforts to the market and to use the multiplying effects of co-operation. The aim is to advance and improve the quality of life. Commenting on the award of this grant, Oxford BioMedica's CEO, Professor Alan Kingsman said: 'It is particularly pleasing to receive a substantial grant from the DTI following substantial peer review of our technology and product rationale. This provides a very strong external endorsement of the technical and commercial potential of BioMedica's immunotherapy programme.' -Ends- For further information, please contact: Oxford BioMedica plc Professor Alan Kingsman, Chief Executive Tel: +44 (0)1865 783 000 City/Financial Enquiries: Mike Wort, James Chandler: Beattie Financial Tel: +44 (0)20 7398 3300 Scientific/Trade Press Enquiries: Sue Charles, Katja Stout: Northbank Communications Tel: +44 (0)20 7321 3870 Notes to Editors 1. Oxford BioMedica plc Established in 1995 as a spin out from Oxford University, Oxford BioMedica plc specialises in the development of novel gene-based therapeutics for the treatment of cancer, neuro-degenerative disease and other disorders with major unmet clinical needs. The development pipeline includes two novel anti-cancer products in clinical trials and a gene therapy treatment for Parkinson's disease, which is in late preclinical studies. This is underpinned by a broad research pipeline and over 70 patent families, about quarter of which are issued. Oxford BioMedica's products use genes as the mediators of a therapeutic effect and/or immune response. The Company's gene therapy products deliver therapeutic molecules in vivo whilst its gene-based immunotherapy products deliver genes that recruit the patient's immune system to mediate a therapeutic effect. The genes are delivered by the Company's highly engineered viruses or cells. BioMedica's lead product TroVax(R) is an anti-cancer therapeutic vaccine expected to be useful against a broad range of tumour types. It is entering Phase II trials in a number of indications including colorectal and renal cancer, and is expected to be ready for Phase III trials at the end of 2003. The Company's second cancer product, MetXia(R), is completing Phase I/II studies in breast cancer. Oxford BioMedica is headquartered in Oxford, UK and has a wholly-owned subsidiary in San Diego, USA. BioMedica has corporate collaborations with Wyeth, IDM, Intervet, Kiadis, Amersham and Arius Research. Oxford BioMedica plc was floated on the Alternative Investment Market of the London Stock Exchange in December 1996, and was promoted to the United Kingdom Listing Authority Official List in April 2001 following a successful £35.5 million fund-raising. Further information is available on the World Wide Web at http:// www.oxfordbiomedica.co.uk This information is provided by RNS The company news service from the London Stock Exchange
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