Director Shareholding

Oxford Biomedica PLC
06 June 2005


                    Oxford BioMedica plc ('the Company')

                Directors' Interest in Shares and Share Options

Oxford BioMedica (OXB:L) The Company today announced that Peter Nolan and Andrew
Wood, both directors of the Company, have exercised options over 153,470 and 
176,799 1p ordinary shares respectively.

The options which have been exercised were granted on 24 September 1998, and if
not exercised, would otherwise lapse on 24 September 2005. Peter Nolan and
Andrew Wood have sold today 93,512 and 107,727 shares respectively at 32.0 pence
per share, this being the amount necessary to fund the exercise of the options
and the associated tax liability. The remaining shares, 59,958 and 69,072
respectively, have been retained, increasing both directors' holdings of 1p
ordinary shares.

The total interests of Peter Nolan and Andrew Wood in the Company's 1p ordinary
shares and share options following these transactions are:
                                        Shares          Share options
             
Peter Nolan                             147,738           730,028
Andrew Wood                             198,022         1,065,891

The exercise price for the options exercised today was 11p per share. The newly
allotted shares are subject to a block listing, so are already listed. Including
these shares, the total number of the Company's issued 1p ordinary shares is now
375,540,162.

Andrew Wood
Company Secretary, Oxford BioMedica plc
6 June 2005



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