Director Shareholding

Oxford Biomedica PLC
22 March 2005


Oxford BioMedica plc ('the Company')

Directors' Interest in Shares and Share Options

Oxford BioMedica (OXB:L) The Company today announced that Peter Nolan and Andrew
Wood, both directors of the Company, had exercised options over 227,731 and
262,346 1p ordinary shares respectively. The exercise price was 15p per share.
The options have been exercised now because they were granted on 7 April 1998,
and if not exercised, would otherwise lapse on 7 April 2005. The option shares
are subject to a block listing, so are already listed. Including the shares
allotted on exercise of these options, the total number of the Company's issued
shares is now 374,019,466. Peter Nolan and Andrew Wood have both sold today all
the shares allotted on the exercise of these options at 19 pence per share.

The total interests of Peter Nolan and Andrew Wood in the Company's 1p ordinary
shares and share options following these transactions are:

                                               Shares            Share options
             --------------------------       ---------             -------

Peter Nolan                                    87,780                  883,498
Andrew Wood                                   128,950                1,242,750

Andrew Wood
Company Secretary, Oxford BioMedica plc
22 March 2005



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