Director/PDMR S/hldg-Amend

Oxford Biomedica PLC
16 December 2005


                                   CORRECTION

           Oxford BioMedica plc ('the Company' or 'Oxford BioMedica')


                            Directors' Shareholdings


The issuer has advised that the following amendment has been made to the
Directors Shareholdings announcement made on 16 December 2005 at 8.23 a.m.


In the second paragraph it states 'However, the share options may only be
exercised if at the time of exercise, or for at least 12 months in the three
years before exercise, the percentage increase in Oxford BioMedica's total
shareholder return exceeds the percentage increase in the FTSE TechMark
Mediscience index since the date of the grant of the share option'.


           Oxford BioMedica plc ('the Company' or 'Oxford BioMedica')


                            Directors' Shareholdings


The Company today announces that on the 15 December 2005 it granted share
options over ordinary shares of 1 pence each in the Company ('share options') to
certain directors, under the Oxford BioMedica 1996 (No.1) share option scheme
('the Scheme'). The exercise price for each of the options is 29 pence per share
and no payment was made in respect of the grant of these share options.


Under the Scheme, the new share options may be exercised between 15 December
2008 and 15 December 2012. However, the share options may only be exercised if
at the time of exercise, or for at least 12 months in the three years before
exercise, the percentage increase in Oxford BioMedica's total shareholder return
exceeds the percentage increase in the FTSE TechMark Mediscience index since the
date of the grant of the share option.

                                               New share options to be granted

Professor Alan Kingsman                                                208,000
Professor Susan Kingsman                                               170,000
Peter Nolan                                                            153,000
Andrew Wood                                                            193,000
Nick Woolf                                                             153,000


Following the grant of these share options, the interests of these directors in
options over ordinary shares of 1 pence each in the Company are:

                                               New share options to be granted

Professor Alan Kingsman                                                578,000
Professor Susan Kingsman                                               475,000
Peter Nolan                                                            883,028
Andrew Wood                                                          1,258,891
Nick Woolf                                                           1,086,124


Andrew Wood

Company Secretary, Oxford BioMedica plc

Tel. [phone]

16 December 2005


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