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Phytopharm PLC 24 September 2007 Company Contact: U.K. Investor Relations Contact: Phytopharm plc FD Dr Daryl Rees CEO David Yates Piers Morgan CFO Ben Atwell +44 1480 437 697 +44 207 831 3113 Phytopharm initiates Stage 3 activities of Joint Development Agreement for Hoodia extract with Unilever Third stage extends to consumer studies GODMANCHESTER, Cambridgeshire, U.K. (24 September 2007) - Phytopharm plc (LSE: PYM) ('Phytopharm') announces today that it continues to make good progress on its weight management product, Hoodia extract in collaboration with Unilever. Phytopharm and Unilever have now initiated certain Stage 3 activities including supply chain expansion and further safety studies which will lead to consumer studies that will evaluate reductions in calorie intake as part of a weight management programme in the general population. Under the terms of the agreement, Phytopharm and Unilever are collaborating on a research and development programme of safety and efficacy studies with a view to bringing new weight management products to market. Stage 2 activities have included successful progression of clinical safety trials, manufacturing and plant cultivation. Phytopharm will continue to receive reimbursement of its further development costs together with an undisclosed royalty on sales of all products containing the extract. Unilever is managing the agronomy programme, undertaking manufacturing and market research activities, and supporting the international patent programme for the products. Phytopharm licensed the global patent rights for the extract of Hoodia, a plant indigenous to South Africa, for incorporation into weight loss products from the South African Council for Scientific and Industrial Research (CSIR) in 1997. Commenting on today's announcement, Kevin Povey, R & D Programme Director, Unilever, said: 'We are satisfied with the good progress to date. The timing is now right to further develop our supply chain and we look forward to advancing this product through additional clinical and consumer studies.' Commenting on today's announcement, Daryl Rees, Chief Executive Officer of Phytopharm, said: 'We are delighted with the continuing progress of our collaboration with one of the world's leading food companies. Our partnership with Unilever provides a fully funded programme and we look forward to generating royalty income from our partner's globally recognised brands in the near future on product launch.' -Ends- Notes to Editors Phytopharm plc Phytopharm is a pharmaceutical development and functional food company whose product leads are generated from medicinal plants. The Company's strategy is to develop these products through 'proof of principle' clinical testing, and then secure partners for late stage development, sales and marketing. Laboratory, manufacturing and clinical work is outsourced to selected specialists, operating under expert in-house management. This operational structure allows access to the best external research facilities whilst maintaining low fixed overheads and a lower development cost structure. Dietary weight management Obesity has reached epidemic proportions globally, with more than 1 billion adults overweight - at least 300 million of them clinically obese - and is a major contributor to the global burden of chronic disease and disability (Source: World Health Organisation). Phytopharm's weight management functional food product is based on an extract of the succulent plant, Hoodia, which is cultivated and harvested under a sophisticated and extensive agronomy programme. Hoodia extract contains a novel satiety stimulator that reduces calorie intake in overweight subjects, as demonstrated by Phytopharm in our double-blind, placebo-controlled clinical study, and has so far demonstrated an excellent safety and tolerability profile in clinical and toxicity studies. Extracts of Hoodia and the active molecules therein are the subject of a global patenting programme, with major patents granted in the US, UK, Europe and Japan and pending in all other major territories. Phytopharm and Unilever have become aware of many companies that are selling products over the Internet and in some stores claiming to contain Hoodia and causing weight loss. Analysis of these products has demonstrated that the great majority of them contain little or no Hoodia. Phytopharm and Unilever have made contact with the relevant authorities concerning this development and are satisfied with the progress being made in these key discussions. Functional Foods Functional foods are foodstuffs that provide health or physiological benefits above their nutritional value and have a health claim on the packaging. Currently gut and heart health products dominate with new interest in areas of weight control, memory and concentration, immune system function and skin health. The global value of functional foods is estimated to be up to $65bn. The growth potential is predicted to be 50% from 2005-2010 with an accelerating trend for new products. More information concerning Phytopharm's activities can be found on its web site at http://www.phytopharm.com This information is provided by RNS The company news service from the London Stock Exchange

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