Holding(s) in Company

Phytopharm PLC
11 June 2007



TR-1: notification of major interests in shares

1. Identity of the issuer or                              Phytopharm plc
the underlying issuer of                               --------------------
existing shares to which voting
rights are attached:
-------------------------------
2. Reason for the notification (please tick the appropriate box or boxes)
--------------------------------------------                                                -------
An acquisition or disposal of voting rights                                            (X) 
An acquisition or disposal of financial instruments which may result in the            ( )
acquisition of shares already issued to which voting rights are attached              -------
--------------------------------------------
An event changing the breakdown of voting rights                                       ( )
--------------------------------------------                                          -------
Other (please specify):___________________________________________                     ( )
--------------------------------------------                                          -------
3. Full name of person(s)       AXA S.a, 25 Avenue Matignon, 75008 Paris and its group of companies
subject to the notification                            --------------------
obligation:
-------------------------------
4. Full name of shareholder(s)
(if different from 3.):                                                        --------------------
-------------------------------
5. Date of the transaction (and                             07/06/2007
date on which the threshold is                         --------------------
crossed or reached if
different)
-------------------------------
6. Date on which issuer                                     08/06/2007
notified:                                              --------------------
-------------------------------
7. Threshold(s) that is/are
crossed or reached:                                                            --------------------
-------------------------------
8. Notified details:
-------------------------------                                              --------------------







A: Voting rights attached to shares
Class/type  Situation previous to the Resulting situation after the triggering
of shares   Triggering transaction    transaction
if possible
using the   Number of    Number of    Number of Number of voting       % of voting
ISIN CODE   Shares       Voting       shares    rights                 rights
                         Rights       Direct    Direct x  Indirect xi  Direct  Indirect
Ordinary 1
Pence        3,328,148    3,328,148    11,000    11,000    3,327,148    0.02     5.98
GB000686972

B: Financial Instruments
Resulting situation after the triggering transaction
Type of     Expiration Exercise/     Number of voting rights that may   % of
financial   date       Conversion    be acquired if the instrument is   voting
instrument             Period/ Date  exercised/ converted.              rights


Total (A+B)
Number of voting rights                      % of voting rights
3,338,148                                    6.00%








9. Chain of controlled undertakings through which the voting rights and/or the
financial instruments are effectively held, if applicable:

   Name of the Company/Fund     Number of Shares     % of issued share capital
AXA UK Investment Co ICVC UK
Smaller Companies Fund                       620                       0.00111
Indirect
Sun Life Pensions Management
Ltd                                       11,000                       0.01978
Direct
AXA Framlington Equity Income          1,851,612                       3.32986
Indirect
AXA Framlington Biotech                1,052,631                       1.89301
Indirect
Framlington onshore private
clients                                  396,483                       0.71302
Indirect
Framlington onshore private
clients                                   25,802                       0.04640
Indirect
                  Total direct            11,000                       0.01978
                Total Indirect         3,327,148                       5.98340
                       Total           3,338,148                       6.00318

Proxy Voting:
10. Name of the proxy holder:
11. Number of voting rights proxy holder will cease to hold:
12. Date on which proxy holder will cease to hold voting rights:

13. Additional           Notification using the total voting rights figure of
information:             55,606,309
14. Contact name:        Zoe McGowan, Company Secretary
15. Contact
telephone
number:                  01480 437697




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