Holding(s) in Company

Phytopharm PLC 07 March 2007 TR-1(i): NOTIFICATION OF MAJOR INTERESTS IN SHARES (1). Identity of the issuer or the underlying issuer of existing shares to which voting rights are attached: Phytopharm plc 2. Reason for the notification An acquisition or disposal of voting rights: ( X ) An acquisition or disposal of financial instruments which may result in the acquisition of shares already issued to which voting rights are attached: ( ) An event changing the breakdown of voting rights: ( ) Other (please specify): ( ) 3. Full name of person(s) subject to the notification obligation: AXA S.a, 25 Avenue Matignon, 75008 Paris and its group of companies 4. Full name of shareholder(s) (if different from 3.): 5. Date of the transaction and date on which the threshold is crossed or reached if different): 07/03/2007 6. Date on which issuer notified: 07/03/2007 7. Threshold(s) that is/are crossed or reached: 6% 8. Notified details: A: Voting rights attached to shares Class or type of Situation previous to the shares triggering transaction if possible using the ISIN CODE Number of Number of shares voting Rights Ordinary 1 Pence 696,569 696,569 GB0006869720 Resulting situation after the triggering transaction Class or type of Number of Number of voting rights % of voting rights shares shares Direct Direct Indirect Direct Indirect Ordinary 1 Pence 1,000 1,000 3,327,148 0.00 6.50 GB0006869720 B: Financial Instruments Resulting situation after the triggering transaction Type of Expiration Date Exercise/Conversion Number of voting % of voting financial Period/ Date rights that may be rights instrument acquired if the instrument is exercised/ converted. Total (A+B) Number of voting rights % of voting rights 3,327,148 6.50% 9. Chain of controlled undertakings through which the voting rights and/or the financial instruments are effectively held, if applicable: Name of the Company / Fund Number of Shares % of issued share capital AXA UK Investment Co ICVC UK 620 0.00121 Smaller Companies Fund Indirect Sun Life Pensions Management Ltd 1,000 0.00195 Direct AXA Framlington Equity Income 1,851,612 3.61778 Indirect AXA Framlington Biotech 1,052,631 2.05669 Indirect Framlington onshore private clients 396,483 .77467 Indirect Framlington onshore private clients 25,802 0.05041 Indirect Total Direct 1,000 0.00195 Total Indirect 3,327,148 6.50076 Total 3,328,148 6.50272 Proxy Voting: 10. Name of the proxy holder: 11. Number of voting rights proxy holder will cease to hold: 12. Date on which proxy holder will cease to hold voting rights: 13. Additional information: Notification using the total voting rights figure of 51,180,893 14. Contact name: Zoe McGowan, Company Secretary 15. Contact telephone number: 01480 437697 This information is provided by RNS The company news service from the London Stock Exchange

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