Holding(s) in Company

Phytopharm PLC
13 May 2005


Re: Disclosure of interests in shares

In accordance with Section 198-202 of the UK Companies Act 1985, FMR Corp, the
parent holding company of Fidelity Management & Research Company (FMRCO), and
Fidelity International Limited (FIL) informed us on 10th May 2005 that it and
its subsidiary companies, including Fidelity Investment Services Ltd (FISL), and
Mr Edward C Johnson 3rd of 82 Devonshire Street, Boston MA 02109, a principal
shareholder of FMR Corp and FIL, no longer have a notifiable interest in the
ordinary shares of Phytopharm plc, amounting to less than 3%, on the basis of
Phytopharm's current issued share capital of 51,180,893 ordinary shares.

Dr Wang Chong 
Chief Financial Officer



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