Holding(s) in Company

Phytopharm PLC 1 March 2005 Re: Disclosure of interests in shares In accordance with Section 198-202 of the UK Companies Act 1985, HBOS plc informed us on 25th February 2005 that it and its subsidiary companies have a notifiable interest in 2,708,821 ordinary shares of Phytopharm plc, amounting to 6.29%, on the basis of Phytopharm's current issued share capital of 43,099,700 ordinary shares. Registered Holder: Fund: Number of Percentage Shares Held; Holding: HSDL Nominees Limited N/A 34 0.00% State Street Nominees Limited a/c 2GEH 2GEH 53,087 0.12% State Street Nominees Limited a/c 2GDX 2GDX 61,251 0.14% State Street Nominees Limited a/c 2GEG 2GEG 444,718 1.03% State Street Nominees Limited a/c 2GDW 2GDW 580,012 1.35% State Street Nominees Limited a/c 2GDS 2GDS 1,569,719 3.64% Aggregate material Holding of HBOS Group 2,708,821 6.29% This information is provided by RNS The company news service from the London Stock Exchange

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