Holding(s) in Company

Phytopharm PLC
14 April 2008



TR-1: notification of major interests in shares

1. Identity of the issuer or the                         Phytopharm plc
underlying issuer of existing shares to               
which voting rights are attached:

2. Reason for the notification (please tick the appropriate box or
boxes)                                                                

An acquisition or disposal of voting rights                             YES
                             
An acquisition or disposal of financial instruments which may result in 
the acquisition of shares already issued to which voting rights are        
attached

An event changing the breakdown of voting rights              
                             
Other (please specify): Placing                                            
                            
3. Full name of person(s) subject to the                RAB Capital plc
notification obligation:                              

4. Full name of shareholder(s) (if   Credit Suisse Client Nominees (UK) Limited
different from 3.):                                   

5. Date of the transaction (and date on                     29/02/08
which the threshold is crossed or reached            
if different)

6. Date on which issuer notified:                           11/04/08
                      
7. Threshold(s) that is/are
crossed or reached:                                           3%
                                 
8. Notified details:                                              

A: Voting rights attached to shares
Class/type  Situation previous to the  Resulting situation after the triggering
of shares   Triggering transaction     transaction
if possible
using the   Number of Number of Voting Number Number of voting   % of voting
ISIN CODE   Shares    Rights           of     rights             rights
                                       shares
                                       Direct Direct Indirect xi Direct Indirect
                                              x
Ordinary 1
Pence       Nil       Nil              Nil    Nil     3,400,326  Nil      3.60%
GB000686972

B: Financial Instruments
Resulting situation after the triggering transaction
Type of     Expiration Exercise/     Number of voting rights that may   % of
financial   date       Conversion    be acquired if the instrument is   voting
instrument             Period/ Date  exercised/ converted.              rights


Total (A+B)
Number of voting rights                      % of voting rights
3,400,326                                    3.60%

9. Chain of controlled undertakings through which the voting rights and/or the
financial instruments are effectively held, if applicable:
RAB Capital plc ('PLC') acts as investment manager for RAB Special Situations
(Master) Fund Limited ('SS') and RAB Innovations (Master) Fund Limited
('Innovations') and makes filings on behalf of these entities under DTR 5.2.1.
PLC does not act as custodian for its clients and therefore the shares are held
in the nominee name of the custodian of its clients, which is Credit Suisse
Client Nominees (UK) Limited for SS and Goldman Sachs Securities (Nominees)
Limited for Innovations.

Proxy Voting:

10. Name of the proxy holder:

11. Number of voting rights proxy holder will cease to hold:

12. Date on which proxy holder will cease to hold voting rights:

13. Additional information:      Notification using the total voting rights 
                                 figure of 94,544,038

14. Contact name:                Zoe McGowan, Company Secretary

15. Contact telephone number:    01480 437697



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