Holding(s) in Company

Phytopharm PLC
09 April 2008



TR-1: notification of major interests in shares

1. Identity of the issuer or                              Phytopharm plc
the underlying issuer of                               
existing shares to which voting
rights are attached:

2. Reason for the notification (please tick the appropriate box or boxes)
                                          
An acquisition or disposal of voting rights  YES
An acquisition or disposal of financial instruments which may result in the 
acquisition of shares already issued to which voting rights are attached 
An event changing the breakdown of voting rights 
Other (please specify): Placing 

3. Full name of person(s)       AXA S.A, 25 Avenue Matignon, 
subject to the notification     75008 Paris and its group of companies
subject to the notification 
obligation:

4. Full name of shareholder(s)
(if different from 3.)

5. Date of the transaction (and                           02/04/08
date on which the threshold is  
crossed or reached if
different)

6. Date on which issuer                                   03/04/08
notified: 


7. Threshold(s)
that is/are
crossed or
reached:                                                       6%

8. Notified details: 

A: Voting rights attached to shares
Class/type  Situation previous to the Resulting situation after the triggering
of shares   Triggering transaction    transaction
if possible
using the  Number of  Number of Number of Number of voting      % of voting
ISIN CODE  Shares     Voting    shares    rights                rights
                      Rights    Direct    Direct x  Indirect xi Direct  Indirect
Ordinary 1
Pence       4,095,079 4,095,079 11,000    11,000    5,737,517   0.01%    6.07%
GB000686972

B: Financial Instruments
Resulting situation after the triggering transaction
Type of     Expiration Exercise/     Number of voting rights that may   % of
financial   date       Conversion    be acquired if the instrument is   voting
instrument             Period/ Date  exercised/ converted.              rights


Total (A+B)
Number of voting rights                      % of voting rights
5,748,517                                    6.08%
9. Chain of controlled undertakings through which the voting rights and/or the
financial instruments are effectively held, if applicable:

   Name of the Company/Fund     Number of Shares     % of issued share capital
AXA UK Investment Co ICVC UK
Smaller Companies Fund                       325                       0.00034
Indirect
Framlington Goldmans                     337,984                       0.35749
Indirect
Sun Life Pensions Management
Ltd                                       11,000                       0.01163
Direct
AXA Framlington Equity Income          3,340,768                       3.53356
Indirect
AXA Framlington Biotech                1,052,631                       1.11338
Indirect
Framlington onshore private
clients                                  477,181                       0.50472
Indirect
Framlington onshore private
clients                                   43,863                       0.04639
Indirect
AXA Framlington St James Place
Internal Equity & Income UT              484,765                       0.51274
Indirect
                  Total direct            11,000                       0.01163
                Total Indirect         5,737,517                       6.06862
                         Total         5,748,517                       6.08025

Proxy Voting:
10. Name of the proxy holder:
11. Number of voting rights proxy holder will cease to hold:
12. Date on which proxy holder will cease to hold voting rights:
13. Additional           Notification using the total voting rights figure of
information:             94,544,038
14. Contact name:        Zoe McGowan, Company Secretary
15. Contact
telephone number:        01480 437697




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