Holding(s) in Company

Phytopharm PLC 28 March 2008 TR-1: Notification of major interests in shares 1. Identity of the issuer or the underlying Phytopharm plc issuer of existing shares to which voting rights are attached: 2. Reason for the notification (please tick the appropriate box or boxes) An acquisition or disposal of voting rights X An acquisition or disposal of financial instruments which may result in the acquisition of shares already issued to which voting rights are attached An event changing the breakdown of voting rights Other (please specify): 3. Full name of person(s) subject to the Deutsche Bank AG notification obligation: 4. Full name of shareholder(s) (if different from 3.): 5. Date of the transaction (and date on which 26/03/2008 the threshold is crossed or reached if different) 6. Date on which issuer notified: 27/03/2008 7. Threshold(s) that is/are crossed or reached: 3% and 4% 8. Notified details: A: Voting rights attached to shares Class/type Situation Resulting situation after the triggering of shares previous to the transaction if possible Triggering using the transaction ISIN CODE Number Number of Number of Number of voting % of voting of Voting shares rights rights Shares Rights Direct Direct x Indirectxi Direct Indirect Ordinary 1 Pence N/A N/A 2,500,000 2,500,000 - 4.5% - GB000686972 B: Financial Instruments Resulting situation after the triggering transaction Type of Expiration Exercise/ Number of voting rights that may % of financial date Conversion be acquired if the instrument is voting instrument Period/ Date exercised/ converted. rights Total (A+B) Number of voting rights % of voting rights 2,500,500 4.5% 9. Chain of controlled undertakings through which the voting rights and/or the financial instruments are effectively held, if applicable: Proxy Voting: 10. Name of the proxy holder: 11. Number of voting rights proxy holder will cease to hold: 12. Date on which proxy holder will cease to hold voting rights: 13. Additional Notification using the total voting rights figure of information: 55,6612,926 14. Contact name: Zoe McGowan, Company Secretary 15. Contact telephonenumber:01480 437697 This information is provided by RNS The company news service from the London Stock Exchange

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