Holding(s) in Company

Phytopharm PLC
20 May 2003


Phytopharm PLC

Phytopharm PLC (the 'Company')

20 May 2003

Notification of major interests in shares


The Company received notification on 19 May 2003 from AMVESCAP PLC (AMVESCAP)
and subsidiary companies on behalf of discretionary clients that following the
purchase of 140,000 shares on 16 May 2003 AMVESCAP has an interest within the
meaning of Part VI of the Act in 8,935,434 Ordinary 1p Shares.  This represents
23.11% of the issued share capital.  Details of that interest, together with a
breakdown between registered holders (as required by Section 202(3) of the Act),
are set out below:-


Vidacos Nominees Limited                                                      6,823,567
HSBC Nominees Limited                                                         1,249,427
Bank of New York Nominees Limited                                             369,918
Chase Nominees Limited                                                        292,000
Northern Trust Nominees Limited                                               135,000
Mellon Bank Pittsburgh Nominees                                               58,572
CM Investment Nominees Limited                                                6,950



None of these shares are beneficially owned by AMVESCAP.  Subsidiary companies
of AMVESCAP have a large number of portfolio management clients for whom they
act as investment manager and investment advisor and by virtue of Section 203 of
the Companies Act 1985 AMVESCAP is deemed to have the same interest in the
shares.



The above holding includes 3,844,362 shares representing 9.94% held by INVESCO
Perpetual Income Fund and registered in the name of Vidacos Nominees Limited.


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