Holding(s) in Company

Phytopharm PLC
2 June 2003


Phytopharm PLC (the 'Company')

Notification of major interests in shares

The Company received notification on 30 May 2003 from AMVESCAP PLC (AMVESCAP) 
and subsidiary companies on behalf of discretionary clients that following the 
purchase of 537,020 shares on 29 May 2003 AMVESCAP has an interest within the 
meaning of Part VI of the Act in 9,763,882 Ordinary 1p Shares. This represents 
25.25% of the issued share capital. Details of that interest, together with a 
breakdown between registered holders (as required by Section 202(3) of the Act),
are set out below:-
 
Vidacos Nominees Limited          7,474,588 
HSBC Nominees Limited             1,278,555 
Bank of New York Nominees Limited   503,533 
Chase Nominees Limited              325,536 
Northern Trust Nominees Limited     174,720 
CM Investment Nominees Limited        6,950

 
None of these shares are beneficially owned by AMVESCAP. Subsidiary companies 
of AMVESCAP have a large number of portfolio management clients for whom they 
act as investment manager and investment advisor and by virtue of Section 203 
of the Companies Act 1985 AMVESCAP is deemed to have the same interest in the 
shares.

The above holding includes 4,021,780 shares representing 10.40% held by 
INVESCO Perpetual Income Fund and 1,296,134 shares representing 3.35% held by 
INVESCO Perpetual UK Growth Fund, both registered in the name of Vidacos 
Nominees Limited.



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