Holding(s) in Company

Phytopharm PLC
18 October 2002


Phytopharm PLC ( the 'Company')

Notification of Major Interests in Shares

The Company received a notification today from AMVESCAP PLC, informing it that
following a purchase of 375,000 shares on 17 October 2002 , AMVESCAP PLC and
subsidiary companies on behalf of discretionary clients have a non beneficial
interest in 5,985,228 ordinary 1p shares, representing 15.50% of the issued
ordinary share capital of the Company.

The Shares are registered in the following names:
Vidacos Nominees Limited                                                         4,760,419
HSBC Nominees Limited                                                            704,455
Chase Nominees Limited                                                           192,000
Bank of New York Nominees Ltd                                                    184,782
Northern Trust Nominees Limited                                                  85,000
Mellon Bank Pittsburgh Nominees                                                  58,572

In addition the Company received a notification today from AMVESCAP PLC,
informing it that, INVESCO Perpetual Income Fund has an interest in 2,460,296
ordinary 1p shares, representing 6.37% of the issued ordinary share capital of
the Company. The shares are registered in the name of Vidacos Nominees Limited.

18 October, 2002


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