Director/PDMR Shareholding

Phytopharm PLC
14 September 2007


NOTIFICATION OF TRANSACTIONS OF DIRECTORS, PERSONS DISCHARGING MANAGERIAL
RESPONSIBILITY OR CONNECTED PERSONS

This form is intended for use by an issuer to make a RIS notification required
by DR 3.1.4R(1.

(1)     An issuer making a notification in respect of a transaction relating to
shares or debentures of the issuer should complete boxes 1 to 16, 23 and 24.

(2)     An issuer making a notification in respect of a derivative relating to
the shares of the issuer should complete boxes 1 to 4, 6, 8, 13, 14, 16, 23 and
24.

(3)     An issuer making a notification in respect of options granted to a
director/person discharging managerial responsibilities should complete boxes 1
to 3 and 17 to 24.

(4)     An issuer making a notification in respect of a financial instrument
relating to the shares of the issuer (other than a debenture) should complete
boxes 1 to 4, 6, 8, 9, 11, 13, 14, 16, 23 and 24.


Please complete all relevant boxes in block capital letters.

  1.  Name of the issuer                   2.  State whether the notification
                                               relates to (i) a transaction
                                               notified in accordance with DR
                                               3.1.4R(1)(a); or
      PHYTOPHARM PLC                           (ii) DR 3.1.4R(1)(b) a disclosure
                                               made in accordance with section
                                               324 (as extended by section 328)
                                               of the Companies Act 1985; or
                                               (iii) both (i) and (ii)
                                               NOTIFICATION RELATES TO (iii)

  3.  Name of person discharging           4.  State whether notification
      managerial responsibilities/             relates to a person connected
      director                                 with a person discharging
                                               managerial responsibilities/
                                               director named in 3 and identify
                                               the connected person
      DR DARYL REES                            AS 3 ABOVE

  5.  Indicate whether the notification    6.  Description of shares (including
      is in respect of a holding of the        class), debentures or derivatives
      person referred to in 3 or 4 or in       or financial instruments relating
      respect of a non-beneficial              to shares
      interest
      AS 3 ABOVE                               OPTIONS OVER ORDINARY SHARES OF 1
                                               PENCE EACH

  7.  Name of registered shareholder(s)    8.  State the nature of the
      and, if more than one, the number        transaction
      of shares held by each of them
                                               GRANT OF AN SAYE SHARE OPTION
                                               UNDER THE PHYTOPHARM SHARESAVE
                                               PLAN 2007

  9.  Number of shares, debentures or     10.  Percentage of issued class
      financial instruments relating to        acquired (treasury shares of that
      shares acquired                          class should not be taken into
                                               account when calculating
                                               percentage)

 11.  Number of shares, debentures or     12.  Percentage of issued class
      financial instruments relating to        disposed (treasury shares of that
      shares disposed                          class should not be taken into
                                               account when calculating
                                               percentage)

 13.  Price per share or value of         14.  Date and place of transaction
      transaction

 15.  Total holding following             16.  Date issuer informed of
      notification and total percentage        transaction
      holding following notification
      (treasury shares of that class
      should not be taken into account
      when calculating percentage)

If a person discharging managerial responsibilities has been granted options by
the issuer complete the following boxes

 17.  Date of grant                          18.  Period during which or date on
                                                  which it can be exercised
      12 SEPTEMBER 2007                           1 OCTOBER 2010 TO 31 MARCH
                                                  2011

 19.  Total amount paid (if any) for grant   20.  Description of shares or
      of the option                               debentures involved (class and
                                                  number)
      NIL                                         19,585 PHYTOHARM PLC ORDINARY
                                                  1 PENCE SHARES

 21.  Exercise price (if fixed at the time   22.  Total number of shares or
      of grant) or indication that price is       debentures over which options
      to be fixed at the time of exercise         held following notification
      EXERCISE PRICE FORTY EIGHT AND ONE                             1,278,559
      QUARTER PENCE PER SHARE

 23.  Any additional information             24.  Name of contact and telephone
                                                  number for queries
                                                  ZOE MCGOWAN
                                                  01480 437697



Name and signature of duly authorised officer of issuer responsible for making
notification
------------------------------------------------
___ZOE MCGOWAN_________________________________________________________

Date of notification _14 SEPTEMBER 2007____________________________________
                                ------------------------------------------------




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