Blocklisting Interim Review

Phytopharm PLC 04 November 2005 BLOCKLISTING SIX MONTHLY RETURN INFORMATION PROVIDED ON THIS FORM MUST BE TYPED OR PRINTED ELECTRONICALLY. To: The FSA Date: 4 November 2005 1. Name of applicant: Phytopharm plc 2. Name of scheme The Phytopharm 1996 Company Share Option Plan 3. Period of return: From 1 May 2005 To 31 October 2005 4. Balance under scheme from previous return: 159,660 Ordinary Shares of 1 pence 5. The amount by which the block scheme has been increased, if the scheme has been increased since the date of the last return: Nil 6. Number of securities issued/allotted under scheme during period: Nil 7. Balance under scheme not yet issued / allotted at end of period 159,660 Ordinary shares of 1 pence 8. Number and class of securities originally listed and the date of admission 400,000 Ordinary Shares of 1 pence on 18 May 2000 9. Total number of securities in issue at the end of the period 51,180,893 Ordinary Shares of 1 pence at 31 October 2005 Name of contact Dr G W Chong Address of contact Corpus Christi House, 9 West Street, Godmanchester, PE29 2HY Telephone number of contact 01480 437 697 Signed by Director/company secretary/suitably experienced employee/duly authorised officer, for and on behalf of Name of applicant Phytopharm plc If you knowingly or recklessly give false or misleading information you may be liable to prosecution. This information is provided by RNS The company news service from the London Stock Exchange

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