Holding(s) in Company

Intl. Biotechnology Trust PLC
03 August 2007


TR-1(i):      NOTIFICATION OF MAJOR INTERESTS IN SHARES

1. Identity of the issuer or the underlying issuer of existing      
shares to which voting rights are attached(ii):

INTERNATIONAL BIOTECHNOLOGY TRUST

2. Reason for the notification     (please tick the appropriate box or boxes)

An acquisition or disposal of voting rights                                  x

An acquisition or disposal of financial instruments which may result in the 
acquisition of shares already issued to which voting rights are attached

An event changing the breakdown of voting rights

Other (please specify):

3. Full name of person(s) subject to the notification obligation   
(iii):

Henderson Global Investors Ltd

4. Full name of shareholder(s) (if different from 3.)(iv):

5. Date of the transaction (and date on which the threshold is                   
crossed or reached if different)(v):

31 July

6. Date on which issuer notified:                                             

1 August

7. Threshold(s) that is/are crossed or reached:                                   

5%

8. Notified details:


A: Voting rights attached to shares
Class/type of      Situation previous to the Resulting situation after the triggering transaction(vii)
shares             Triggering transaction
                   (vi)
 if possible using Number of    Number of    Number of   Number of voting       % of voting rights
the ISIN CODE      Shares       Voting       shares      rights ix
                                Rights viii  Direct      Direct  x   Indirect   Direct     Indirect
                                                                     xi
Ordinary 25 pence  4,202,538    4,202,538    4,192,060   4,192,060              5.93
shares


B: Financial Instruments
Resulting situation after the triggering transaction xii
Type of financial    Expiration date Exercise/ Conversion      Number of voting rights    % of voting
instrument           xiii            Period/ Date xiv          that may be acquired if    rights
                                                               the instrument is
                                                               exercised/ converted.

      CFD                                                           1,122,142                  0


Total (A+B)
Number of voting rights                            % of voting rights

5,314,202                                               5.93


9. Chain of controlled undertakings through which the voting rights and/or the 
financial instruments are effectively held, if applicable xv:



Proxy Voting:

10. Name of the proxy holder:

11. Number of voting rights proxy holder will cease to hold:

12. Date on which proxy holder will cease to hold voting rights:


13. Additional information:                                               Total voting rights: 70,592,664

14. Contact name:                                                                 Louise Richard

15. Contact telephone number:                                                      020 7658 6501

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