Holding(s) in Company

Intl. Biotechnology Trust PLC
09 February 2007



TR-1(i): NOTIFICATION OF MAJOR INTERESTS IN SHARES



1. Identity of the issuer or the underlying issuer of existing shares to which
voting rights are attached (ii):



International Biotechnology Trust plc



2. Reason for the notification (please place an X inside the appropriate bracket
/s):



An acquisition or disposal of voting rights: (X)



An acquisition or disposal of financial instruments which may result in the
acquisition of shares already issued to which voting rights are attached: (    )



An event changing the breakdown of voting rights: (    )



Other (please specify) : (    )



N/A



3. Full name of person(s) subject to the notification obligation (iii):



East Riding of Yorkshire Council



4. Full name of shareholder(s) (if different from 3.) (iv):



-



5. Date of the transaction (and date on which the threshold is crossed or
reached if different) (v):



02 February 2007



6. Date on which issuer notified:



05 February 2007



7. Threshold(s) that is/are crossed or reached:



4%



8. Notified details:



4.249%



A: Voting rights attached to shares




Class/type of shares if possible           Situation previous to the Triggering transaction (vi)
using the ISIN CODE
                                  Number of shares                   Number of voting Rights (viii)


    Ordinary 25 pence shares            1,150,000                            1,150,000

          GB0004559349





Resulting situation after the triggering transaction (vii)


Class/type of shares if      Number of shares         Number of voting rights (ix)      % of voting rights
possible using the ISIN CODE
                             Direct                   Direct (x)   Indirect (xi)        Direct      Indirect


  Ordinary 25 pence shares          2,000,000          2,000,000           N/A            4.249%        N/A

        GB0004559349                                                                      as at 5
                                                                                         February
                                                                                           2007



B: Financial Instruments

Resulting situation after the triggering transaction (xii)


Type of         Expiration Date       Exercise/Conversion       Number of voting rights     % of voting rights
financial       (xiii)                Period/ Date (xiv)        that may be acquired if the
instrument                                                      instrument is exercised/
                                                                converted.


      N/A                N/A                     N/A                        N/A                     N/A



Total (A+B)
Number of voting rights        % of voting rights


          2,000,000                       4.249%



9. Chain of controlled undertakings through which the voting rights and/or the
financial instruments are effectively held, if applicable (xv):



N/A



Proxy Voting:



10. Name of the proxy holder:



N/A



11. Number of voting rights proxy holder will cease to hold:



N/A



12. Date on which proxy holder will cease to hold voting rights:



N/A



13. Additional information:



Calculation based on 47,065,467 Ordinary Shares in issue as at 5 February 2007



14. Contact name:



Carolyn Johnson



15. Contact telephone number:



01482 394149



Annex to Notification Of Major Interests In Shares (xvi)



A: Identity of the person or legal entity subject to the notification obligation



Full name (including legal form for legal entities):



East Riding of Yorkshire Council



Contact address (registered office for legal entities):



Investment Section

PO Box 164

Church Street

Goole

DN14 5Y2



Phone number:



01482 394149



Other useful information (at least legal representative for legal persons):



Carolyn Johnson



B: Identity of the notifier, if applicable (xvii)



Full name:



Louise Richard



Contact address:



Schroder Investment Management Limited



Phone number:



0207 658 6501



Other useful information (e.g. functional relationship with the person or legal
entity subject to the notification obligation):



N/A



C: Additional information :



Date of Notification: 9 February 2007


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