Holding(s) in Company

Intl. Biotechnology Trust PLC
19 February 2003


19 February 2003

By Facsimile

RNS
Old Broad Street
London
EC2N 1HP


Dear Sirs

                    Substantial Share Interest Notification

We are writing to advise that the Company was notified on 19 February 2003 that
Deutsche Bank AG and its subsidiary companies have a notifiable interest in
1,500,000 ordinary shares of 25p each, representing 3.09% of the 48,615,467
shares in issue.



Yours faithfully,

John Spedding
For Schroder Investment Management Limited
Secretaries


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