Product Development Update

Syntopix Group plc 01 August 2006 For immediate release 1 August 2006 SYNTOPIX GROUP PLC ('Syntopix' or 'the Company') FIRST PRODUCTS PROGRESS INTO DEVELOPMENT Syntopix Group plc (AIM: SYN), the drug discovery and development company focused on dermatological diseases, is delighted to announce that three candidates from its research pipeline, for which patent applications have been made, will be taken forward into clinical product development for the treatment of acne and staphylococcal infections. In accordance with the Company's plans and as outlined in the Company's admission document, SYN-24-0017 will become the first candidate to enter pre-clinical development as a topical remedy for the prevention and treatment of skin infections due to Staphylococcus aureus. In parallel, a synergistic combination of SYN-24-0017 with a metal salt will be developed as a topical treatment for acne vulgaris. An additional remedy for acne will also be developed from a synergistic combination of SYN-24-0401 with SYN-24-0403 or its salt. The compounds all have a history of use in man in line with the Company's reduced risk business model. SYN-24-0017 is an anti-oxidant present in a wide variety of food and cosmetic products. SYN-24-0401 is an antifungal ingredient in personal care products. Compounds related to SYN-24-0403 are present in some combination products for the treatment of secondarily infected atopic dermatitis. SYN-24-0017 and SYN-24-0401 are effective antimicrobials when used alone, but Syntopix has shown that their activity can be enhanced when used in combination with certain metal salts or with SYN-24-0403 respectively. Commenting on this important milestone, CEO Rod Adams said: 'We are extremely pleased to have made significant scientific advancements since the flotation of Syntopix in March this year. We have selected three lead candidates from our portfolio to enter formulation and clinical studies in line with expectations and I am very excited about the quality of our development programme.' For further information please contact: Syntopix Group plc 0845 125 9204 Gwyn Humphreys, Chairman Rod Adams, Chief Executive Officer www.syntopix.com KBC Peel Hunt Ltd 020 7418 8900 Megan MacIntyre Buchanan Communications 020 7466 5000 Mark Court, Tim Anderson, Mary-Jane Johnson About Syntopix Group plc Syntopix Group plc began as a spin-out company from the University of Leeds. The Syntopix strategy is designed to reduce the risks and costs of drug development by avoiding the use of new chemical entities. Flotation on AiM in March 2006 enabled the Company to take its first candidate products into the development pipeline. The Company's therapeutic focus is currently on acne and staphylococcal skin infections. Syntopix has a collaborative approach and will work with partners in the pharmaceutical and healthcare sector to expedite a rapid route to market. This information is provided by RNS The company news service from the London Stock Exchange

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