Transaction in Own Shares

GlaxoSmithKline PLC 22 February 2007 GlaxoSmithKline plc (the "Company") announces that in accordance with the authority granted by shareholders at the Company's Annual General Meeting on 17 May 2006 it purchased 860,000 of its Ordinary shares of 25 pence each ("shares") on 22 February 2007 at a price of 1448.0571 pence per share. The Company intends to hold these shares in Treasury. Following the purchase of these shares, the Company holds 255,887,678 of its shares in Treasury. The Company has 5,752,734,147 shares in issue (excluding Treasury shares). This number represents the total voting rights in the Company and may be used by shareholders as the denominator for the calculations by which they can determine if they are required to notify their interest in, or a change to their interest in the Company under the Financial Services Authority's Disclosure and Transparency Rules. This announcement does not constitute, or form part of, an offer or any solicitation of an offer to purchase or subscribe for securities in any jurisdiction and is in conformity with the Transparency Directive's transitional provision 6. This information is provided by RNS The company news service from the London Stock Exchange ND POSILFLDFLIFFID

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