Holding(s) in Company

GlaxoSmithKline PLC
21 April 2005



GLAXOSMITHKLINE plc - Notification of Major Interests in Shares


GlaxoSmithKline plc (the Company) yesterday received notification from Barclays
plc in compliance with Part VI of the Companies Act 1985 (as amended), that on
14 April 2005 it had the following interests in the Company's Ordinary Shares of
25 pence:

 Registered Holder                                      Current shareholding

 Barclays Global Fund Advisors                                    13,253,089
 Barclays Life Assurance Co Ltd                                    8,626,453
 Barclays Private Bank and Trust Ltd                                   1,000
 Barclays Private Bank and Trust Ltd                                 267,671
 Barclays Global Investors Ltd                                   101,445,177
 Barclays Capital Securities Ltd                                  28,289,611
 Gerrard Ltd                                                       1,975,464
 Barclays Ban Trust Company Ltd                                      937,538
 Barclays Capital Inc                                              1,066,000
 Barclays Global Investors Japan Ltd                               4,602,669
 Barclays Private Bank Ltd                                         1,785,032
 Barclays Global Investors Australia Ltd                           2,207,508
 Barclays Global Investors Japan Trust & Banking                   7,439,862
 Barclays Global Investors, N.A.                                  70,693,867
 Barclays Private Bank & Trust Ltd                                    11,495
 TOTAL                                                           242,602,436


Barclays plc's total holding has increased from 3.91 per cent to 4.14 per cent
of the issued share capital of the Company (excluding shares held in Treasury).


S M Bicknell
Company Secretary

21 April 2005


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