GSK Earnings Guidance

GlaxoSmithKline PLC
28 October 2005

London, UK - 28th October 2005
GlaxoSmithKline plc

                    GlaxoSmithKline plc's Earnings Guidance

As announced on 27th October 2005 GSK's earnings guidance for 2005 is 
'mid-teens' EPS percentage growth in constant exchange rate (CER) terms.

The web cast material accompanying the third quarter results inadvertently
included, for a short period of time, an internal estimate for 2005 EPS of 79.9p
and growth of approximately 17 percent in CER terms. This estimate is consistent
with the Company's earnings guidance but is a point estimate in time and subject
to a number of assumptions which are regularly reviewed and can change depending
on business performance and other circumstances.

The Company's earnings guidance remains 'mid-teens' EPS percentage growth in CER
terms.

S M Bicknell
Company Secretary

28th October 2005

GlaxoSmithKline - one of the world's leading research-based pharmaceutical and
healthcare companies - is committed to improving the quality of human life by
enabling people to do more, feel better and live longer. For company information
visit www.gsk.com.




Enquiries:        UK Media                           Philip Thomson        [phone]
                                                     David Mawdsley        [phone]
                                                     Chris Hunter-Ward     [phone]
                                                     Alice Hunt            [phone]

                  US Media                           Nancy Pekarek         [phone]
                                                     Mary Anne Rhyne       [phone]
                                                     Patricia Seif         [phone]

                  European Analyst / Investor        Duncan Learmouth      [phone]
                                                     Anita Kidgell         [phone]
                                                     Jen Hill              [phone]

                  US Analyst / Investor              Frank Murdolo         [phone]
                                                     Tom Curry             [phone]


Cautionary statement regarding forward-looking statements

Under the safe harbor provisions of the US Private Securities Litigation Reform
Act of 1995, the Company cautions investors that any forward-looking statements
or projections made by the Company, including those made in this Announcement,
are subject to risks and uncertainties that may cause actual results to differ
materially from those projected.  Factors that may affect the Group's operations
are described under 'Risk Factors' in the Operating and Financial Review and
Prospects in the Company's Annual Report 2004.




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